Association of Serum 25-Hydroxyvitamin D Concentrations With All-Cause and Cause-Specific Mortality Among Individuals With Diabetes
Wan Z, Guo J, Pan A, Chen C, Liu L, Liu G
Diabetes care · 179 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- National Key Research and Development Program of China
- Government
- Hubei Province Science Fund for Distinguished Young Scholars
- Grants
- National Key Research and Development Program of China (2017YFC0907504); National Natural Science Foundation of China (81930124); National Natural Science Foundation of China (2017YFC0907504); National Key Research and Development Program of China (81930124)
Based on 3 listed funder(s).
Publication
- Published
- 2020-11-09 · Diabetes Care · vol. 44 · issue 2 · pp. 350–357
- Publisher
- American Diabetes Association
- Cited
- 224 citations · more than 99% of similar papers · 12.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 35 works
- Access
- Free to read
- Research areas
- Vitamin D Research Studies · Nutritional Studies and Diet · Vitamin C and Antioxidants Research
- Keywords
- Medicine, National Health and Nutrition Examination Survey, Diabetes mellitus, National Death Index, Hazard ratio, Internal medicine, Vitamin D and neurology, Cause of death, Proportional hazards model, Insulin resistance, Type 2 diabetes, vitamin D deficiency, Population, Endocrinology, Gastroenterology, Disease, Confidence interval, Environmental health
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, vitamin d deficiency, vitamin d, nutrition surveys, cause of death, risk factors, adult
6 authors
From CN
- Zhenzhen WanHuazhong University of Science and Technology
- Jingyu GuoHuazhong University of Science and Technology
- An PanHuazhong University of Science and Technology
- Chen ChenHuazhong University of Science and Technology
- Liegang LiuHuazhong University of Science and Technology
- Gang Liu · correspondingHuazhong University of Science and Technology
Abstract
Objective
The evidence regarding vitamin D status and mortality among people with diabetes is scarce. This study aimed to examine the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among adults with diabetes.
Research design and methods
This study included 6,329 adults with diabetes from the Third National Health and Nutrition Examination Survey (NHANES III) and NHANES 2001-2014. Death outcomes were ascertained by linkage to National Death Index records through 31 December 2015. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% CIs for mortality from all causes, cardiovascular disease (CVD), and cancer.
Results
The weighted mean (95% CI) level of serum 25(OH)D was 57.7 (56.6, 58.8) nmol/L, and 46.6% had deficient vitamin D (1c, blood lipids, and C-reactive protein at baseline (all P trend P 75 nmol/L were 0.59 (0.43, 0.83) for all-cause mortality (P trend = 0.003), 0.50 (0.29, 0.86) for CVD mortality (P trend = 0.02), and 0.49 (0.23, 1.04) for cancer mortality (P trend = 0.12).
Conclusions
Higher serum 25(OH)D levels were significantly associated with lower all-cause and CVD mortality. These findings suggest that maintaining adequate vitamin D status may lower mortality risk in individuals with diabetes.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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