Effect of magnesium supplementation on emergence delirium and postoperative pain in children undergoing strabismus surgery: a prospective randomised controlled study
Lee JH, Choi S, Lee M, Jang YE, Kim EH, Kim JT, Kim HS
BMC anesthesiology · 10 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Seoul National University
- University or hospital
- College of Medicine, Seoul National University
- Grants
- Seoul National University (grant 800-20140532)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-11-18 · BMC Anesthesiol · vol. 20 · issue 1 · p. 289
- Publisher
- BioMed Central
- Cited
- 17 citations · more than 76% of similar papers · 0.9× the field average
- References
- 31 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Intensive Care Unit Cognitive Disorders · Magnesium in Health and Disease · Anesthesia and Neurotoxicity Research
- Keywords
- Medicine, Emergence delirium, Anesthesia, Incidence (geometry), Delirium, Anxiety, Randomized controlled trial, Regimen, Surgery, Sevoflurane, Intensive care medicine
- MeSH
- humans, strabismus, magnesium, intraoperative care, prospective studies, dietary supplements, child, preschool, female, male, republic of korea, emergence delirium, postoperative pain
7 authors
From KR
- Ji‐Hyun LeeSeoul National University Hospital
- Seungeun ChoiSeoul National University Hospital
- Minkyoo LeeSeoul National University Hospital
- Young‐Eun JangSeoul National University Hospital
- Eun‐Hee Kim · correspondingSeoul National University Hospital
- Jin‐Tae KimSeoul National University Hospital
Abstract
Background
The benefits of intraoperative magnesium supplementation have been reported. In this prospective, randomized study, the effects of magnesium supplementation during general anaesthesia on emergence delirium and postoperative pain in children were evaluated.
Methods
A total of 66 children aged 2 to 5 years who underwent strabismus surgery were assigned to the magnesium or to the control group. Preoperative anxiety was assessed using the modified Yale Preoperative Anxiety Scale. After anaesthesia induction, the magnesium group received an initial loading dose of 30 mg/kg magnesium sulphate over 10 min and, then, continuous infusion of 10 mg/kg per h until 10 min before the end of the surgery. The control group received an equal volume of normal saline via the same regimen. The Paediatric Anaesthesia Emergence Delirium (PAED) score, pain score, and respiratory events were assessed at the postanaesthetic care unit.
Results
Data obtained from 65 children were analyzed. The PAED and pain scores of the two groups did not differ significantly. There were 26 of 33 (78.8%) and 27 of 32 (84.4%) children with emergence delirium in the control and the magnesium groups, respectively (odds ratio 0.69, 95% CI 0.19-2.44; p = 0.561). The preoperative anxiety score was not significantly correlated with the PAED score. The incidence of respiratory events during the emergence period did not differ significantly between the two groups.
Conclusions
Magnesium supplementation during anaesthesia had no significant effects on the incidence of emergence delirium or postoperative pain in children undergoing strabismus surgery.
Trial registration
ClinicalTrials.gov ( NCT03132701 ). Prospectively registered May 8, 2017.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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