Funded in part by Fundación BBVA, Banco Bilbao Vizcaya Argentaria
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain
Madore C, Leyrolle Q, Morel L, Rossitto M, Greenhalgh AD, Delpech JC, Martinat M, Bosch-Bouju C, Bourel J, Rani B, Lacabanne C, Thomazeau A, Hopperton KE, Beccari S, Sere A, Aubert A, De Smedt-Peyrusse V, Lecours C, Bisht K, Fourgeaud L, Gregoire S, Bretillon L, Acar N, Grant NJ, Badaut J, Gressens P, Sierra A, Butovsky O, Tremblay ME, Bazinet RP, Joffre C, Nadjar A, Layé S
Nature communications · 134 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Fundación BBVA
- Nonprofit
- National Alliance for Research on Schizophrenia and Depression
- Government
- Agence Nationale de la Recherche
- Government
- Institut National de la Santé et de la Recherche Médicale
- Nonprofit
- Fondation pour la Recherche Médicale
- Government
- Eusko Jaurlaritza
- Government
- Ministerio de Economía y Competitividad
- Government
- Centre National de la Recherche Scientifique
- Company
- Banco Bilbao Vizcaya Argentaria
- University or hospital
- Hospital for Sick Children
- Nonprofit
- Fédération pour la Recherche sur le Cerveau
- University or hospital
- LabEx BRAIN
- University or hospital
- Université de Paris
- Government
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
- Government
- Canadian Institutes of Health Research
- Government
- National Institute of Neurological Disorders and Stroke
- Government
- CHIST-ERA
- Government
- CIHR
- Government
- NINDS NIH HHS
- Grants
- Fondation pour la Recherche Médicale (DEQ20170336724); Fundación BBVA (PI_2016_1_0011); Ministerio de Economía y Competitividad (RYC‐2013‐12817); Agence Nationale de la Recherche (2017-); Agence Nationale de la Recherche (ANR‐10‐LABX‐43); Agence Nationale de la Recherche (ANR-10-IDEX-0001); LabEx BRAIN (ANR‐10‐LABX‐43); Agence Nationale de la Recherche (ANR-12-BSV4-0025); Eusko Jaurlaritza (PI_2016_1_0011); Institut National de la Santé et de la Recherche Médicale (US 005); National Institute of Neurological Disorders and Stroke (R01NS088137); Fondation pour la Recherche Médicale (ANR-10-LABX-43); Fédération pour la Recherche sur le Cerveau (ANR-11-INBS-0011); Institut National de la Santé et de la Recherche Médicale (ANR-11-INBS-0011); Agence Nationale de la Recherche (ANR-11-INBS); Fondation pour la Recherche Médicale (2017-1R30237-00013179); Agence Nationale de la Recherche (ANR-12); Agence Nationale de la Recherche (ANR-11-INBS-0011); Agence Nationale de la Recherche (ANR-10); Agence Nationale de la Recherche (ANR-10-BLAN-1414); Agence Nationale de la Recherche (ANR-10-LABX); Fondation pour la Recherche Médicale (00070700); Fondation pour la Recherche Médicale (ANR-11-INBS-0011); Ministerio de Economía y Competitividad (BFU2015-66689)
Based on 19 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-11-30 · Nat Commun · vol. 11 · issue 1 · p. 6133
- Publisher
- Nature Portfolio
- Cited
- 178 citations · more than 98% of similar papers · 7.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 91 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Neuroinflammation and Neurodegeneration Mechanisms · Fatty Acid Research and Health · Immune Response and Inflammation
- Keywords
- Polyunsaturated fatty acid, Microglia, Synaptic pruning, Offspring, Hippocampal formation, Hippocampus, Biology, Neuroscience, Central nervous system, Phagocytosis, Inflammation, Cell biology, Immunology, Biochemistry, Pregnancy, Fatty acid, Genetics
- MeSH
- brain, hippocampus, microglia, neurons, animals, humans, mice, lipoxygenase, fatty acids, omega-3, phagocytosis, gene expression regulation, developmental, homeostasis, neuronal plasticity, dietary supplements, female, male, neurodevelopmental disorders
33 authors
From US, FR, IT, CA, ES, GB
- Charlotte MadoreBrigham and Women's Hospital; Harvard University; Université de Bordeaux; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro; Institut Polytechnique de Bordeaux
- Quentin LeyrolleUniversité de Bordeaux; Inserm; Délégation Paris 7; Université Paris Cité; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro; Institut Polytechnique de Bordeaux; NeuroDiderot
- Lydie J. MorelUniversité de Bordeaux; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro; Institut Polytechnique de Bordeaux
- Moïra RossittoUniversité de Bordeaux; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro; Institut Polytechnique de Bordeaux
- Andrew D. GreenhalghUniversité de Bordeaux; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro; Institut Polytechnique de Bordeaux
- Jean-Christophe DelpechUniversité de Bordeaux; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro; Institut Polytechnique de Bordeaux
Abstract
Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental diseases in Humans. However, the n-3 PUFAs deficiency-mediated mechanisms affecting the development of the central nervous system are poorly understood. Active microglial engulfment of synapses regulates brain development. Impaired synaptic pruning is associated with several neurodevelopmental disorders. Here, we identify a molecular mechanism for detrimental effects of low maternal n-3 PUFA intake on hippocampal development in mice. Our results show that maternal dietary n-3 PUFA deficiency increases microglia-mediated phagocytosis of synaptic elements in the rodent developing hippocampus, partly through the activation of 12/15-lipoxygenase (LOX)/12-HETE signaling, altering neuronal morphology and affecting cognitive performance of the offspring. These findings provide a mechanistic insight into neurodevelopmental defects caused by maternal n-3 PUFAs dietary deficiency.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.