Dose-Response Effect of Dietary Nitrate on Muscle Contractility and Blood Pressure in Older Subjects: A Pilot Study
Gallardo EJ, Gray DA, Hoffman RL, Yates BA, Moorthi RN, Coggan AR
The journals of gerontology. Series A, Biological sciences and medical sciences · 29 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Indiana University-Purdue University Indianapolis
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Government
- National Center for Advancing Translational Sciences
- Government
- NIA NIH HHS
- University or hospital
- Indiana University Purdue University Indianapolis
- Government
- NIAMS NIH HHS
- Government
- NHLBI NIH HHS
- Government
- NCATS NIH HHS
- Government
- NIDDK NIH HHS
- University or hospital
- Office of the Vice Provost for Research
- Grants
- National Center for Advancing Translational Sciences (UL1TR002529); National Institute of Diabetes and Digestive and Kidney Diseases (K23 DK102824); National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR072581); National Institute on Aging (R21 AG053606); National Heart, Lung, and Blood Institute (R34HL138253); National Institutes of Health (P30AR072581); National Institutes of Health (UL1 TR002529); National Institutes of Health (R34HL138253); National Institutes of Health (R21 AG053606); National Institutes of Health (K23 DK102824)
Based on 14 listed funder(s).
Publication
- Published
- 2020-12-10 · J Gerontol A Biol Sci Med Sci · vol. 76 · issue 4 · pp. 591–598
- Publisher
- Oxford University Press
- Cited
- 38 citations · more than 94% of similar papers · 4.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 46 works
- Access
- Open access (repository copy)
- Research areas
- Cardiovascular and exercise physiology · Diet and metabolism studies · Thermoregulation and physiological responses
- Keywords
- Contractility, Blood pressure, Nitrate, Medicine, Pharmacology, Internal medicine, Cardiology, Biology, Ecology
- MeSH
- humans, beta vulgaris, nitrates, nitric oxide, breath tests, monitoring, physiologic, pilot projects, double-blind method, blood pressure, muscle contraction, dose-response relationship, drug, dietary supplements, aged, female, male, healthy volunteers, phytochemicals, fruit and vegetable juices, outcome assessment, health care
6 authors
From US
- Edgar J. GallardoIndiana University – Purdue University Indianapolis
- Derrick A. GrayIndiana University – Purdue University Indianapolis
- Richard Leigh HoffmanIndiana University – Purdue University Indianapolis
- Brandon A. YatesIndiana University – Purdue University Indianapolis
- Ranjani N. MoorthiIndiana University – Purdue University Indianapolis
- Andrew R. Coggan · correspondingIndiana University – Purdue University Indianapolis
Abstract
We have recently demonstrated that dietary nitrate, a source of nitric oxide (NO) via the nitrate → nitrite → NO enterosalivary pathway, can improve muscle contractility in healthy older men and women. Nitrate ingestion has also been shown to reduce blood pressure in some, but not all, studies of older individuals. However, the optimal dose for eliciting these beneficial effects is unknown. A pilot randomized, double-blind, placebo-controlled crossover study was therefore performed to determine the effects of ingesting 3.3 mL/kg of concentrated beetroot juice containing 0, 200, or 400 µmol/kg of nitrate in 9 healthy older subjects (mean age 70 ± 1 years). Maximal knee extensor power (Pmax) and speed (Vmax) were measured ~2.5 hours after nitrate ingestion using isokinetic dynamometry. Blood pressure was monitored periodically throughout each study. Pmax (in W/kg) was higher (p < .05) after the lower dose (3.9 ± 0.4) compared to the placebo (3.7 ± 0.4) or higher dose (3.7 ± 0.4). Vmax (in rad/s) also tended to be higher (p = .08) after the lower dose (11.9 ± 0.7) compared to the placebo (10.8 ± 0.8) or higher dose (11.2 ± 0.8). Eight out of 9 subjects achieved a higher Pmax and Vmax after the lower versus the higher dose. These dose-related changes in muscle contractility generally paralleled changes in breath NO levels. No significant changes were found in systolic, diastolic, or mean arterial blood pressure. A lower dose of nitrate increases muscle speed and power in healthy older individuals, but these improvements are lost at a higher dose. Blood pressure, on the other hand, is not reduced even with a higher dose.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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