Metabolic Impact of Intermittent Fasting in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Interventional Studies
Borgundvaag E, Mak J, Kramer CK
The Journal of clinical endocrinology and metabolism · 64 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Intramural Funds
Based on 1 listed funder(s).
Publication
- Published
- 2020-12-15 · J Clin Endocrinol Metab · vol. 106 · issue 3 · pp. 902–911
- Publisher
- Oxford University Press
- Cited
- 101 citations · more than 86% of similar papers · 1.8× the field average
- References
- 46 works
- Access
- Free to read
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Medicine, Weight loss, Glycated hemoglobin, Meta-analysis, Body mass index, Internal medicine, Obesity, Type 2 diabetes, Type 2 Diabetes Mellitus, Randomized controlled trial, Diabetes mellitus, Population, Endocrinology
- MeSH
- humans, diabetes mellitus, type 2, obesity, weight loss, blood glucose, hypoglycemic agents, fasting, history, 20th century, history, 21st century, adult, female, male, randomized controlled trials as topic
3 authors
From CA
- Emily BorgundvaagMount Sinai Hospital
- Jessica MakMount Sinai Hospital; University of Toronto
- Caroline Kaercher Kramer · correspondingMount Sinai Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute
Abstract
Context
Intermittent fasting (IF) has been proposed as a weight-loss strategy with additional cardiometabolic benefits in individuals with obesity. Despite its growing popularity, the effect of IF in patients with type 2 diabetes (T2DM) remains unclear.
Objective
We conducted a systematic review and meta-analysis to evaluate the metabolic impact of IF compared to standard diet in patients with T2DM.
Methods
Embase, PubMed, and clinicaltrials.gov between 1950 and August 12, 2020 were searched for randomized, diet-controlled studies evaluating any IF intervention in adults with T2DM. We examined the impact of IF on weight loss and glucose-lowering by calculating pooled estimates of the absolute differences in body weight and glycated hemoglobin A1c (HbA1c) compared to a control group using a random-effects model.
Results
Seven studies (n = 338 participants; mean body mass index [BMI] 35.65, mean baseline HbA1c 8.8%) met our inclusion criteria. IF induced a greater decrease in body weight by -1.89 kg (95% CI, -2.91 to -0.86 kg) compared to a regular diet, with no significant between-study heterogeneity (I2 21.0%, P = .28). The additional weight loss induced by IF was greater in studies with a heavier population (BMI > 36) (-3.43 kg [95% CI, -5.72 to -1.15 kg]) and in studies of shorter duration (≤ 4 months) (-3.73 kg [95% CI, -7.11 to -0.36 kg]). IF was not associated with further reduction in HbA1c compared to a standard diet (HbA1c -0.11% [95% CI, -0.38% to 0.17%]).
Conclusion
Current evidence suggests that IF is associated with greater weight loss in patients with T2DM compared with a standard diet, with a similar impact on glycemic control.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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