Health Effects of Alternate-Day Fasting in Adults: A Systematic Review and Meta-Analysis
Cui Y, Cai T, Zhou Z, Mu Y, Lu Y, Gao Z, Wu J, Zhang Y
Frontiers in nutrition · 38 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support
- Government
- Beijing Municipal Administration of Hospitals
- Government
- Taishan Scholar Foundation of Shandong Province
- Grants
- National Natural Science Foundation of China (81870525); Beijing Municipal Administration of Hospitals (DFL20190502); Beijing Municipal Administration of Hospitals (ZYLX201820); Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (DFL20190502); National Natural Science Foundation of China (81801429); National Natural Science Foundation of China (81870525, 81801429); Beijing Municipal Administration of Hospitals (81801429); Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (81801429); National Natural Science Foundation of China (tsqn201909199); National Natural Science Foundation of China (81572835); National Natural Science Foundation of China (ZYLX201820); National Natural Science Foundation of China (DFL20190502); Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201820); Taishan Scholar Foundation of Shandong Province (tsqn201909199)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-11-24 · Front Nutr · vol. 7 · p. 586036
- Publisher
- Frontiers Media
- Cited
- 61 citations · more than 73% of similar papers · 1.0× the field average
- References
- 70 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Nutritional Studies and Diet
- Keywords
- Medicine, Meta-analysis, Randomized controlled trial, Body mass index, Blood pressure, Internal medicine, Weight loss, Insulin resistance, Obesity, High-density lipoprotein, Endocrinology, Cholesterol
8 authors
From CN
- Yuanshan CuiQingdao University; Capital Medical University; Yuhuangding Hospital; Beijing Tian Tan Hospital
- Tong CaiQingdao University; Binzhou Medical University; Shandong University of Aeronautics; Yuhuangding Hospital
- Zhongbao ZhouCapital Medical University; Beijing Tian Tan Hospital
- Yingmei MuQingdao University; Yuhuangding Hospital
- Youyi LuQingdao University; Yuhuangding Hospital
- Zhenli GaoQingdao University; Yuhuangding Hospital
Abstract
Background: Alternate-day fasting (ADF) method is becoming more and more popular among adults. This meta-analysis aims to evaluate the effects of ADF on adults. Methods: Randomized controlled trials (RCTs) of ADF were searched using PubMed (1988 to March 2020), EMBASE (1995 to March 2020), and the Cochrane Controlled Trials Register. A systematic review was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-analyses. The datum was calculated by RevMan version 5.3.0. The original references for relating articles were also reviewed. Results: Seven randomized controlled trials involving 269 participants (152 in the ADF group and 117 in the control group) were studied. In this meta-analysis, compared with the control group, the ADF group showed statistically significant reductions in weight (p p p = 0.001), low-density lipoprotein (p = 0.01), triglycerides (p = 0.02), fat mass (p = 0.002), lean mass (p = 0.002), systolic blood pressure (p = 0.003), diastolic blood pressure (p = 0.007), and total calorie intake (p = 0.007). At the same time, the analysis demonstrated that the ADF group had a same effect compared with control group in aspects of high-density lipoprotein (p = 0.27), homeostasis model assessment-insulin resistance (p = 0.55), and fasting blood sugar (p = 0.09). Conclusions: This meta-analysis suggests that ADF is a viable diet strategy for weight loss, and it has a substantial improvement in risk indicators for diseases in obese or normal people.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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