Funded in part by U.S. Highbush Blueberry Council
Blueberry phenolics are associated with cognitive enhancement in supplemented healthy older adults
Rutledge GA, Sandhu AK, Miller MG, Edirisinghe I, Burton-Freeman BB, Shukitt-Hale B
Food & function · 29 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Government
- U.S. Department of Agriculture
- Industry group
- U.S. Highbush Blueberry Council
- Government
- National Institutes of Health
- Grants
- National Institutes of Health (T32 AG00002941)
Based on 3 listed funder(s).
Publication
- Published
- 2020-12-15 · Food Funct · vol. 12 · issue 1 · pp. 107–118
- Publisher
- Royal Society of Chemistry
- Cited
- 51 citations · more than 98% of similar papers · 7.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Paywalled
- Research areas
- Ginkgo biloba and Cashew Applications · Medicinal Plants and Neuroprotection · Phytochemicals and Antioxidant Activities
- Keywords
- Cognition, Food science, Cognitive decline, Medicine, Chemistry, Dementia, Internal medicine, Psychiatry
- MeSH
- humans, phenols, nootropic agents, double-blind method, cognition, dietary supplements, aged, middle aged, female, male, blueberry plants
6 authors
From US
- Grant A. RutledgeTufts University; Agricultural Research Service
- Amandeep Kaur SandhuIllinois Institute of Technology
- Marshall G. MillerTufts University; Agricultural Research Service
- Indika EdirisingheIllinois Institute of Technology
- Britt Marie Burton‐FreemanIllinois Institute of Technology
- Barbara Shukitt‐Hale · correspondingTufts University; Agricultural Research Service
Abstract
Blueberries (BB) contain an array of bioactive phenolic compounds that may play a protective role against various age-related diseases. Here we explored the metabolic fate of BB phenolics and their relationship to cognitive function after chronic (90 days) supplementation of freeze-dried BB (24 g d-1, equivalent to 1 cup of fresh BB) or control in a randomized, double-blind, parallel study with 38 healthy older adults (60-75 years). Blood samples were collected at fasting (t = 0 h) and 2 h after a breakfast meal on days 0 (no treatment), 45, and 90, and a battery of cognitive tests was also conducted on these days. Hippuric acid, phloroglucinaldehyde, syringic acid, ferulic acid-glucuronide, cyanidin-3-O-galactoside, cyanidin-3-O-glucoside, malvidin-3-O-galactoside, malvidin-3-O-glucoside, peonidin-3-O-xyloside, peonidin glucuronide, and petunidin-3-O-glucoside concentrations were significantly altered after 90 days of BB consumption compared to control. Stepwise regression was used to assess the relationship between significantly altered concentrations of plasma phenolics and observed improvements in cognition. Among participants in the BB group, changes in switch errors on the task-switching test (TST) from day 0 to 90 were associated with changes in postprandial levels of plasma ferulic acid-glucuronide, syringic acid, and malvidin-3-galactoside (R2 = 0.521, p 2 = 0.807, p < 0.001). These findings demonstrate that the addition of easily achievable quantities of BB to the diets of older adults significantly alters levels of circulating phenolic compounds which are related to improvements in cognition.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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