Funded in part by Alcon Research Institute
Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption: A Gene-Diet Interaction Study from the UK Biobank
Kim J, Aschard H, Kang JH, Lentjes MAH, Do R, Wiggs JL, Khawaja AP, Pasquale LR, Modifiable Risk Factors for Glaucoma Collaboration
Ophthalmology · 69 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Industry funded
- University or hospital
- New York Eye and Ear Infirmary of Mount Sinai
- Government
- UK Research and Innovation
- Nonprofit
- Moorfields Eye Charity
- Government
- Medical Research Council
- University or hospital
- National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology
- Government
- National Eye Institute
- Company
- Alcon Research Institute
- Government
- NEI NIH HHS
- Grants
- National Eye Institute (R01EY015473); Medical Research Council (MC_PC_17228)
Based on 8 listed funder(s).
Publication
- Published
- 2020-12-16 · Ophthalmology · vol. 128 · issue 6 · pp. 866–876
- Publisher
- Elsevier BV
- Cited
- 84 citations · more than 96% of similar papers · 4.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Coffee research and impacts · Glaucoma and retinal disorders · Drug-Induced Ocular Toxicity
- Keywords
- Medicine, Glaucoma, Intraocular pressure, Mendelian randomization, Caffeine, Quartile, Logistic regression, Ophthalmology, Internal medicine, Genotype, Confidence interval, Genetics
- MeSH
- humans, glaucoma, genetic predisposition to disease, caffeine, risk factors, follow-up studies, prospective studies, cross-sectional studies, intraocular pressure, adult, aged, middle aged, biological specimen banks, female, male, mendelian randomization analysis, united kingdom
8 authors
From US, FR, SE, GB
- Jihye Kim · correspondingHarvard University
- Hugues AschardHarvard University; Institut Pasteur
- Jae Hee KangBrigham and Women's Hospital; Harvard University
- Marleen A. H. LentjesÖrebro University
- Ron DoIcahn School of Medicine at Mount Sinai
- Janey L. WiggsMassachusetts Eye and Ear Infirmary; Harvard University
Abstract
Purpose
We examined the association of habitual caffeine intake with intraocular pressure (IOP) and glaucoma and whether genetic predisposition to higher IOP modified these associations. We also assessed whether genetic predisposition to higher coffee consumption was related to IOP.
Design
Cross-sectional study in the UK Biobank.
Participants
We included 121 374 participants (baseline ages, 39-73 years) with data on coffee and tea intake (collected 2006-2010) and corneal-compensated IOP measurements in 2009. In a subset of 77 906 participants with up to 5 web-based 24-hour-recall food frequency questionnaires (2009-2012), we evaluated total caffeine intake. We also assessed the same relationships with glaucoma (9286 cases and 189 763 controls).
Methods
We evaluated multivariable-adjusted associations with IOP using linear regression and with glaucoma using logistic regression. For both outcomes, we examined gene-diet interactions using a polygenic risk score (PRS) that combined the effects of 111 genetic variants associated with IOP. We also performed Mendelian randomization using 8 genetic variants associated with coffee intake to assess potential causal effects of coffee consumption on IOP.
Main outcome measures
Intraocular pressure and glaucoma.
Results
Mendelian randomization analysis did not support a causal effect of coffee drinking on IOP (P > 0.1). Greater caffeine intake was associated weakly with lower IOP: the highest (≥232 mg/day) versus lowest (trend = 0.01). However, the IOP PRS modified this association: among those in the highest IOP PRS quartile, consuming > 480 mg/day versus interaction = 0.01). The relationship between caffeine intake and glaucoma was null (P ≥ 0.1). However, the IOP PRS also modified this relationship: compared with those in the lowest IOP PRS quartile consuming no caffeine, those in the highest IOP PRS quartile consuming ≥ 321 mg/day showed a 3.90-fold higher glaucoma prevalence (Pinteraction = 0.0003).
Conclusions
Habitual caffeine consumption was associated weakly with lower IOP, and the association between caffeine consumption and glaucoma was null. However, among participants with the strongest genetic predisposition to elevated IOP, greater caffeine consumption was associated with higher IOP and higher glaucoma prevalence.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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