Evaluation of Vitamin D Metabolism in Patients with Type 1 Diabetes Mellitus in the Setting of Cholecalciferol Treatment
Povaliaeva A, Pigarova E, Zhukov A, Bogdanov V, Dzeranova L, Mel'nikova O, Pekareva E, Malysheva N, Ioutsi V, Nikankina L, Rozhinskaya L
Nutrients · 8 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Russian Science Foundation
- Grants
- Russian Science Foundation (19-15-00243)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-12-18 · Nutrients · vol. 12 · issue 12 · p. 3873
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 18 citations · more than 79% of similar papers · 1.2× the field average
- References
- 53 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · Diabetes and associated disorders
- Keywords
- Cholecalciferol, Internal medicine, Vitamin D and neurology, Endocrinology, Medicine, Vitamin, Diabetes mellitus, Parathyroid hormone, Calcifediol, Type 2 Diabetes Mellitus, vitamin D deficiency, Type 2 diabetes, Calcium
- MeSH
- humans, diabetes mellitus, type 1, cholecalciferol, calcifediol, calcitriol, 24,25-dihydroxyvitamin d 3, 25-hydroxyvitamin d 2, parathyroid hormone, vitamin d, vitamin d-binding protein, administration, oral, case-control studies, prospective studies, adult, female, male, young adult, glycated hemoglobin
11 authors
From RU
- Alexandra A. Povaliaeva · correspondingEndocrinology Research Center
- Ekaterina Aleksandrovna PigarovaEndocrinology Research Center
- Artem Yu. ZhukovEndocrinology Research Center
- Viktor P. BogdanovEndocrinology Research Center
- Larisa Konstantinovna DzeranovaEndocrinology Research Center
- Olga Georgievna Mel'nikovaEndocrinology Research Center
Abstract
In this prospective controlled study, we examined 25 adults with adequately controlled (HbA1c level 3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3), free 25(OH)D, vitamin D-binding protein (DBP) and parathyroid hormone (PTH) as well as serum and urine biochemical parameters were performed before the intake and on Days 1, 3 and 7 after the administration. The studied groups had no significant differences in baseline parameters except that the patients with diabetes showed higher baseline levels of free 25(OH)D (p p > 0.05 vs. r = 0.88, p 3 levels observed in the diabetes group throughout the study since Day 1 (p 3 levels and the therapeutic response to cholecalciferol is similar to that in healthy individuals.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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