Nut consumption and the prevalence and severity of non-alcoholic fatty liver disease
Semmler G, Semmler G, Bachmayer S, Wernly S, Wernly B, Niederseer D, Huber-Schönauer U, Stickel F, Aigner E, Datz C
PloS one · 14 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2020-12-31 · PLoS One · vol. 15 · issue 12 · p. e0244514
- Publisher
- Public Library of Science
- Cited
- 17 citations · more than 82% of similar papers · 1.5× the field average
- References
- 66 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nuts composition and effects · Peanut Plant Research Studies · Botany, Ecology, and Taxonomy Studies
- Keywords
- Medicine, Metabolic syndrome, Fatty liver, Internal medicine, Odds ratio, Insulin resistance, Dyslipidemia, Gastroenterology, Diabetes mellitus, Prediabetes, Confounding, Type 2 diabetes, Disease, Endocrinology, Insulin, Obesity
- MeSH
- liver, humans, nuts, liver cirrhosis, disease progression, severity of illness index, diet surveys, prevalence, risk factors, feeding behavior, sex factors, adult, aged, middle aged, female, male, non-alcoholic fatty liver disease, metabolic syndrome
9 authors
From AT, CH
- Georg SemmlerParacelsus Medical University; Krankenhaus Oberndorf
- Sebastian BachmayerParacelsus Medical University; Krankenhaus Oberndorf
- Sarah WernlyParacelsus Medical University; Krankenhaus Oberndorf
- Bernhard WernlyParacelsus Medical University
- David NiederseerUniversity Hospital Zurich
- Ursula Huber-SchönauerParacelsus Medical University; Krankenhaus Oberndorf
Abstract
Background
Nut consumption has been associated with reduced inflammation, insulin resistance, and oxidative stress. However, the influence on the prevalence and severity of non-alcoholic fatty liver disease (NAFLD) has yet to be evaluated.
Methods
4655 subjects were included as part of a colorectal carcinoma screening program (SAKKOPI) between 07/2010 and 07/2019 and analyzed 2020. Patients were characterized using biochemical and metabolic parameters, as well as a detailed questionnaire on dietary habits. The diagnosis of NAFLD was established using abdominal ultrasound. Consumption of nuts was graded as: no consumption or <1 time/week, 1-6 times/week, 1 time/day and ≥2 times/day.
Results
Mean age was 58.5±9.8years with a mean BMI of 26.5±4.7kg/m2. 2058 (44.2%) patients suffered from the metabolic syndrome, 2407 (51.6%) had arterial hypertension, 2287 (49.1%) showed prediabetes/diabetes, 1854 (39.4%) had dyslipidemia and 1984 patients (43.5%) were diagnosed with NAFLD. Prevalence of metabolic syndrome (1219 [48.7%] vs. 605 [40.2%] vs. 189 [37.4%] vs. 45 [31.7%], p2.67: aOR: 0.551 [95%CI: 0.338-0.898], p = 0.017; Forns-Index >6.9: aOR: 0.585 [95%CI: 0.402-0.850], p = 0.005).
Conclusions
Nut consumption might exert beneficial effects on the prevalence of NAFLD in males. The negative association with advanced fibrosis warrants further investigation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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