The Effect of Repeated Whole-Body Cryotherapy on Sirt1 and Sirt3 Concentrations and Oxidative Status in Older and Young Men Performing Different Levels of Physical Activity
Wojciak G, Szymura J, Szygula Z, Gradek J, Wiecek M
Antioxidants (Basel, Switzerland) · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Narodowym Centrum Nauki
- Government
- National Science Centre
- Grants
- Narodowym Centrum Nauki (2015/17/N/NZ7/01039)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-12-31 · Antioxidants (Basel) · vol. 10 · issue 1 · p. 37
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 14 citations · more than 71% of similar papers · 0.6× the field average
- References
- 67 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Exercise and Physiological Responses · Thermoregulation and physiological responses · Medical and Biological Ozone Research
- Keywords
- SIRT3, Antioxidant, Superoxide dismutase, Glutathione peroxidase, Oxidative stress, Internal medicine, Catalase, Endocrinology, Medicine, Chemistry, Biochemistry, Enzyme, Sirtuin
5 authors
From PL
- Gabriela Wojciak · correspondingUniversity of Physical Culture in Kraków
- Jadwiga SzymuraUniversity of Physical Culture in Kraków
- Zbigniew SzygułaUniversity of Physical Culture in Kraków
- Joanna GradekUniversity of Physical Culture in Kraków
- Magdalena Więcek · correspondingUniversity of Physical Culture in Kraków
Abstract
Background
The activity of antioxidant enzymes and sirtuins (Sirt) decreases along with age, which is counteracted by aerobic training. Sirtuins increase antioxidant defence. Whole-body cryotherapy (WBC) increases total antioxidant capacity (TAC) in young men. The aim of our study was to assess the impact of 24 WBC treatments on the blood concentration of selected sirtuins and the level of antioxidant defence as well as oxidative stress index of training and non-training men depending on age.
Methods
The study involved 40 males. In each group, there were 10 non-training older and young men (60 NTR and 20 NTR), and 10 older and young long-distance runners (60 TR, 20 TR). During an 8-week period, participants underwent 24 WBC treatments (3 min -130 °C), which were performed three times a week (Monday, Wednesday, Friday). The concentrations of Sirt1, Sirt3, TAC, total oxidative status and the activity of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in the blood were determined before 1 WBC and after 1 WBC, 12 WBC and 24 WBC.
Results
After 1 WBC, the activity of GPx and the concentration of Sirt1 and TAC in 60 TR and TAC in 60 NTR increased. After 12 WBC, the level of Sirt1 in 20 NTR and SOD in 20 TR increased. After 24 WBC, the level of Sirt1 increased in 60 TR and in 20 NTR, Sirt3 in 60 TR and SOD in 20 TR.
Conclusions
Cryogenic temperatures increase blood levels of Sirt1 and Sirt3 and systemic antioxidant defence in men, but the effect is dependent on age, level of performed physical activity and the number of applied treatments.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.