Effects of time-restricted feeding in weight loss, metabolic syndrome and cardiovascular risk in obese women
Schroder JD, Falqueto H, Mânica A, Zanini D, de Oliveira T, de Sá CA, Cardoso AM, Manfredi LH
Journal of translational medicine · 107 citations
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Universidade Comunitária da Região de Chapecó
- University or hospital
- Universidade Federal da Fronteira Sul
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Unclassified
- UFFS
- Grants
- Universidade Federal da Fronteira Sul (480/GR/UFFS/2018); Universidade Federal da Fronteira Sul (1010/GR/UFFS/2018)
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-01-06 · J Transl Med · vol. 19 · issue 1 · p. 3
- Publisher
- BioMed Central
- Cited
- 148 citations · more than 99% of similar papers · 12.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Enhanced Recovery After Surgery · Circadian rhythm and melatonin
- Keywords
- Medicine, Overweight, Metabolic syndrome, Weight loss, Obesity, Waist, Anthropometry, Body mass index, Population, Internal medicine, Type 2 diabetes, Diabetes mellitus, Physiology, Endocrinology, Environmental health
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, obesity, weight loss, body mass index, risk factors, quality of life, middle aged, female, overweight, metabolic syndrome, heart disease risk factors
8 authors
From BR
- Jéssica Daniela SchröderUniversidade Federal da Fronteira Sul
- Hugo FalquetoUniversidade Federal da Fronteira Sul
- Aline MânicaCommunity University of Chapecó Region - Unochapecó
- Daniela ZaniniUniversidade Federal da Fronteira Sul
- Tácio de OliveiraUniversidade Federal da Fronteira Sul
- Clodoaldo Antônio De SáCommunity University of Chapecó Region - Unochapecó
Abstract
Background
The increasing prevalence of overweight and obesity among the worldwide population has been associated with a range of adverse health consequences such as Type 2 diabetes and cardiovascular diseases. The metabolic syndrome (MetS) is a cluster of cardiometabolic abnormalities that occur more commonly in overweight individuals. Time-restricted feeding (TRF) is a dietary approach used for weight loss and overall health. TRF may be an option for those subjects who struggle with extreme restriction diets with foods that generally do not belong to an individual's habits.
Objective
The purpose of this study was to determine the effect of TRF on body composition and the association of weight loss with metabolic and cardiovascular risks in obese middle-aged women.
Methods
A non-randomized controlled clinical trial was performed over 3 months in obese women (TRF group, n = 20, BMI 32.53 ± 1.13 vs. Control n = 12, BMI 34.55 ± 1.20). The TRF protocol adopted was 16 h without any energy intake followed by 8 h of normal food intake.
Main outcomes and measures
Anthropometric measurements, body composition, blood biomarkers, cardiovascular risk in 30 years (CVDRisk30y), and quality of life were evaluated at baseline and after the 3 months.
Results
TRF was effective in reducing weight (~ 4 kg), BMI, % of body fat (%BF), waist circumference from baseline without changes in blood biomarkers associated with MetS. TRF promoted a reduction in CVDRisk30y (12%) wich was moderately correlated with %BF (r = 0.62, n = 64, p < 0.001) and %MM (r = - 0.74, n = 64, p < 0.001).
Conclusions
TRF protocol reduces body weight without changes in biomarkers related to MetS. In addition, the anthropometric evaluation that predicts %BF and %MM could be used as an approach to follow individuals engaged in the TRF regimen since they correlate with cardiovascular risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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