Timing of acute passive heating on glucose tolerance and blood pressure in people with type 2 diabetes: a randomized, balanced crossover, control trial
James TJ, Corbett J, Cummings M, Allard S, Young JS, Towse J, Carey-Jones K, Eglin C, Hopkins B, Morgan C, Tipton M, Tipton M, Saynor ZL, Shepherd AI
Journal of applied physiology (Bethesda, Md. : 1985) · 14 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Portsmouth
Based on 1 listed funder(s).
Publication
- Published
- 2021-01-07 · J Appl Physiol (1985) · vol. 130 · issue 4 · pp. 1093–1105
- Publisher
- American Physiological Society
- Cited
- 19 citations · more than 82% of similar papers · 1.6× the field average
- References
- 86 works
- Access
- Paywalled
- Research areas
- Thermoregulation and physiological responses · Adipose Tissue and Metabolism · Exercise and Physiological Responses
- Keywords
- Crossover study, Blood pressure, Ingestion, Medicine, Diabetes mellitus, Type 2 diabetes, Internal medicine, Heart rate, Endocrinology, Cardiology, Placebo
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, insulin, glucose, blood glucose, heating, blood pressure
13 authors
From GB
- Thomas J. JamesPortsmouth Hospitals NHS Trust; University of Portsmouth
- Jo CorbettUniversity of Portsmouth
- Michael CummingsPortsmouth Hospitals NHS Trust
- Sharon AllardPortsmouth Hospitals NHS Trust
- John S. YoungUniversity of Portsmouth
- Jonathan TowseUniversity of Portsmouth
Abstract
Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia and progressive insulin resistance, leading to macro and microvascular dysfunction. Passive heating has potential to improve glucose homeostasis and act as an exercise mimetic. We assessed the effect of acute passive heating before or during an oral glucose tolerance test (OGTT) in people with T2DM. Twelve people with T2DM were randomly assigned to the following three conditions: 1) 3-h OGTT (control), 2) 1-h passive heating (40°C water) 30 min before an OGTT (HOT-OGTT), and 3) 1-h passive heating (40°C water) 30 min after commencing an OGTT (OGTT-HOT). Blood glucose concentration, insulin sensitivity, extracellular heat shock protein 70 (eHSP70), total energy expenditure (TEE), heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were recorded. Passive heating did not alter blood glucose concentration [control: 1,677 (386) arbitrary units (AU), HOT-OGTT: 1,797 (340) AU, and OGTT-HOT: 1,662 (364) AU, P = 0.28], insulin sensitivity (P = 0.15), or SBP (P = 0.18) but did increase eHSP70 concentration in both heating conditions [control: 203.48 (110.81) pg·mL-1; HOT-OGTT: 402.47 (79.02) pg·mL-1; and OGTT-HOT: 310.00 (60.53) pg·mL-1, P P = 0.001], increased HR in both heating conditions (P P NEW & NOTEWORTHY This is the first study to investigate the timing of acute passive heating on glucose tolerance and extracellular heat shock protein 70 concentration ([eHSP70]) in people with type 2 diabetes. The principal novel findings from this study were that both passive heating conditions: 1) did not reduce the area under the curve or peak blood glucose concentration, 2) elevated heart rate, and 3) increased [eHSP70], which was blunted by glucose ingestion, while passive heating following glucose ingestion, 4) increased total energy expenditure, and 5) reduced diastolic blood pressure.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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