Effectively Prescribing Oral Magnesium Therapy for Hypertension: A Categorized Systematic Review of 49 Clinical Trials
Rosanoff A, Costello RB, Johnson GH
Nutrients · 27 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Possibly industry funded
- Authors
- At least one author declares a financial tie to industry
Based on full-text disclosure statement.
Publication
- Published
- 2021-01-10 · Nutrients · vol. 13 · issue 1 · p. 195
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 41 citations · more than 79% of similar papers · 1.4× the field average
- References
- 108 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Thyroid and Parathyroid Surgery
- Keywords
- Medicine, Magnesium, Blood pressure, Placebo, Clinical trial, Internal medicine, Oral administration, Chemistry
- MeSH
- humans, cardiovascular diseases, hypertension, magnesium, antihypertensive agents, administration, oral, risk factors, blood pressure, databases, factual, clinical trials as topic
3 authors
From US
- Aaron J. Rosanoff · corresponding
- Rebecca B. Costello
- Guy H. JohnsonJohnson & Johnson (United States)
Abstract
Trials and meta-analyses of oral magnesium for hypertension show promising but conflicting results. An inclusive collection of 49 oral magnesium for blood pressure (BP) trials were categorized into four groups: (1) Untreated Hypertensives; (2) Uncontrolled Hypertensives; (3) Controlled Hypertensives; (4) Normotensive subjects. Each group was tabulated by ascending magnesium dose. Studies reporting statistically significant (p 600 mg/day; 600 mg/day). Where magnesium did not lower BP, other cardiovascular risk factors showed improvement. Conclusion: Controlled Hypertensives and Normotensives do not show a BP-lowering effect with oral Mg therapy, but oral magnesium (≥240 mg/day) safely lowers BP in Uncontrolled Hypertensive patients taking antihypertensive medications, while >600 mg/day magnesium is required to safely lower BP in Untreated Hypertensives; <600 mg/day for non-medicated hypertensives may not lower both SBP and DBP but may safely achieve other risk factor improvements without antihypertensive medication side effects.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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