TCF7L2 polymorphisms, nut consumption, and the risk of metabolic syndrome: a prospective population based study
Hosseinpour-Niazi S, Bakhshi B, Zahedi AS, Akbarzadeh M, Daneshpour MS, Mirmiran P, Azizi F
Nutrition & metabolism · 6 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- University or hospital
- Shahid Beheshti University of Medical Sciences
- University or hospital
- Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
- Grants
- Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences (18360)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-01-12 · Nutr Metab (Lond) · vol. 18 · issue 1 · p. 10
- Publisher
- BioMed Central
- Cited
- 12 citations · more than 72% of similar papers · 1.0× the field average
- References
- 51 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nuts composition and effects · Nutritional Studies and Diet · Oral Health Pathology and Treatment
- Keywords
- Medicine, Confounding, Metabolic syndrome, Hazard ratio, Internal medicine, Interquartile range, Prospective cohort study, Odds ratio, Weight gain, Population, Nut, Lower risk, Obesity, Confidence interval, Environmental health, Body weight
7 authors
From IR
- Somayeh Hosseinpour‐NiaziResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Bahar BakhshiResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Asiyeh Sadat ZahediResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Mahdi AkbarzadehResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- MARYAM SADAT DANESHPOUR · correspondingResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Parvin Mirmiran · correspondingNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
Abstract
Background
The aim of this study was to investigate whether two variants of the TCF7L2 (rs7903146 and rs12255372) modify the association between nut consumption and the risk of metabolic syndrome (MetS). Additionally, the modifying effect of weight change during follow-up on these associations was investigated.
Material and methods
We prospectively studied 1423 participants of the Tehran Lipid and Glucose study aged 19-74 years who were followed-up for dietary assessment using a validated, semi-quantitative food frequency questionnaire. Multivariable-adjusted Cox regression was used to estimate hazard ratios (HRs) for MetS events. Genotyping was performed by Human Omni Express-24-v1-0 chip.
Results
Over a median 8.9 years of follow-up, 415 new cases of MetS were documented. The median nut consumption was 20.0 g/week (Interquartile Range (IQR): 8.6-38.9 g/week). Regarding the rs7903146 genotype, in carriers of T allele (CT + TT), highest tertile of nut consumption was associated with a reduced risk of MetS after adjusting for confounders (HR: 0.67 (0.50-0.91)). Regarding the rs12255372 genotype, highest versus lowest tertile of nut consumption in participants with T allele (GT + TT) resulted in 34% reduction of MetS risk after adjustment for confounders (HR: 0.66 (0.49-0.69)). After stratification by weigh change (< 7% or ≥ 7% weight gain), in individuals with ≥ 7% weight gain, highest tertile of nut consumption was associated with reduced risk of MetS among the risk allele of rs7903146. In the risk allele of rs12255372, among individuals with < 7% weight gain, third tertile of nuts intake reduced the risk of MetS, after adjustment for confounders.
Conclusion
Higher consumption of nuts may reduces the risk of MetS in T-risk allele of the TCF7L2 rs7903146 and rs12255372 variants and weight change may modify this association.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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