Serial whole-body cryotherapy in fibromyalgia is effective and alters cytokine profiles
Klemm P, Becker J, Aykara I, Asendorf T, Dischereit G, Neumann E, Müller-Ladner U, Lange U
Advances in rheumatology (London, England) · 18 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2021-01-13 · Adv Rheumatol · vol. 61 · issue 1 · p. 3
- Publisher
- Elsevier BV
- Cited
- 34 citations · more than 92% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 47 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Fibromyalgia and Chronic Fatigue Syndrome Research · Exercise and Physiological Responses · Infrared Thermography in Medicine
- Keywords
- Medicine, Fibromyalgia, Cryotherapy, Visual analogue scale, Internal medicine, Cytokine, Interleukin 6, Pathological, Physical therapy, Gastroenterology, Oncology, Surgery
- MeSH
- humans, fibromyalgia, tumor necrosis factor-alpha, interleukin-1, interleukin-6, interleukin-10, cytokines, pain measurement, treatment outcome, cryotherapy, case-control studies, prospective studies, time factors, middle aged, patient satisfaction, female, male
8 authors
From DE
- Philipp Klemm · correspondingJustus-Liebig-Universität Gießen; Kerckhoff Klinik
- Johanna Sabine BeckerJustus-Liebig-Universität Gießen; Kerckhoff Klinik
- Iris AykaraJustus-Liebig-Universität Gießen; Kerckhoff Klinik
- Thomas AsendorfUniversitätsmedizin Göttingen
- Gabriel DischereitJustus-Liebig-Universität Gießen; Kerckhoff Klinik
- Elena NeumannJustus-Liebig-Universität Gießen; Kerckhoff Klinik
Abstract
Introduction
Whole-body cryotherapy (WBC) has shown to be beneficial in the treatment of fibromyalgia (FM). There is cumulative evidence that cytokines play a crucial role in FM. It's unknown whether clinical effects of WBC can be demonstrated at the molecular level and how long the effects last.
Methods
We compared effects of serial WBC (6 sessions (- 130 °C in 6 weeks) in FM patients and healthy controls (HC). Primary outcome was the change in pain level (visual analogue scale 0-100 mm) after 6 sessions. Secondary outcomes were a change in disease activity (revised Fibromyalgia Impact Questionnaire) and pain after 3 sessions and 3 months after discontinued therapy and in cytokine levels (interleukin (IL-)1, IL-6, tumor necrosis factor α (TNF-α) and IL-10). The patients' opinions on the satisfaction, effectiveness and significance of WBC were evaluated.
Results
Twenty-three FM patients and 30 HC were enrolled. WBC resulted in a significant reduction in pain and disease activity after 3 and 6 sessions. No clinical benefit could be measured 3 months after discontinued treatment. Overall, probands were satisfied with WBC and considered WBC to be important and effective. FM patients had significantly different levels of IL-1, IL-6, TNF-α and IL-10 at each reading point compared to HC. Levels of IL-1, IL-6 and IL-10 were significantly altered over time in FM patients. Compared to HC FM patients showed a significantly different response of IL1, - 6 and - 10 to WBC.
Conclusion
Serial WBC is a fast acting and effective treatment for FM. Proven effects of WBC may be explained by changes in cytokines.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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