Efficacy of Magnesium Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Meta-analysis
Chua FB, Cinco JE, Paz-Pacheco E
Journal of the ASEAN Federation of Endocrine Societies · 5 citations
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2017-05-31 · J ASEAN Fed Endocr Soc · vol. 32 · issue 1 · pp. 38–45
- Publisher
- ASEAN Federation of Endocrine Societies
- Cited
- 4 citations · more than 1% of similar papers · 0.0× the field average
- References
- 33 works
- Access
- Open access (free to publish) · CC-BY-NC
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Keywords
- Medicine, Glycemic, Meta-analysis, Type 2 diabetes, Magnesium, Internal medicine, Diabetes mellitus, Endocrinology
3 authors
From PH
- Francis Bryant Chua · correspondingThe Medical City Ortigas; University of Asia and the Pacific
- Jude Erric CincoThe Medical City Ortigas; University of Asia and the Pacific
- Elizabeth T. Paz-PachecoThe Medical City Ortigas; University of Asia and the Pacific
Abstract
Objective
To evaluate if magnesium supplementation, in addition to standard therapy, improves fasting blood sugar (FBS) and/or glycosylated hemoglobin (HbA1c) in patients with type 2 diabetes mellitus (T2DM) compared to placebo or other comparator.
Methodology
We searched MEDLINE/PubMed, Cochrane Library, Acta Medica Philippina, Health Research and Development Information Network (HERDIN) and references of reviewed journals from 1966 to July 2015 using the following search terms: "magnesium" OR "magnesium supplementation" OR "magnesium replacement", AND randomized controlled trial AND diabetes OR diabetes mellitus OR non-insulin dependent diabetes mellitus OR diabetic OR diab* (with MeSH, where available). Studies were retrieved and rated independently using the standards provided by The Cochrane Collaboration. High quality trials were included in a systematic review and meta-analysis.
Results
Of the 689 records screened, 10 studies were included in the qualitative synthesis and 7 studies in the meta-analysis. Pooled data showed a non-significant trend towards improvement in glycemic control in the magnesium-treated group (mean difference -0.19, CI -0.58 to 0.21). There was a stronger but still non-significant trend in T2DM patients with hypomagnesemia (mean difference -1.16, CI -2.92 to 0.6).
Conclusion
Routine magnesium supplementation for improvement in glycemic control in T2DM patients cannot be recommended based on data from included studies in this meta-analysis.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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