Funded in part by JC USA, Inc.
Effect of time restricted eating on body weight and fasting glucose in participants with obesity: results of a randomized, controlled, virtual clinical trial
Peeke PM, Greenway FL, Billes SK, Zhang D, Fujioka K
Nutrition & diabetes · 110 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- U.S. Department of Health and Human Services
- University or hospital
- Louisiana Clinical and Translational Science Center
- Government
- National Institutes of Health
- Government
- National Institute of General Medical Sciences
- Government
- U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
- Company
- JC USA, Inc.
- Government
- U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences
- Government
- NIGMS NIH HHS
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Institute of General Medical Sciences (U54‐ GM104940); Louisiana Clinical and Translational Science Center (U54GM104940); U.S. Department of Health and Human Services (1 U54 GM104940); National Institute of General Medical Sciences (GM104940); Louisiana Clinical and Translational Science Center (1 U54 GM104940); Louisiana Clinical and Translational Science Center (GM104940); National Institutes of Health (3u54gm104940-06s1); National Institutes of Health (U54‐GM104940); National Institutes of Health (1U54‐GM‐104940); National Institutes of Health (GM104940); National Institute of General Medical Sciences (1 U54 GM104940)
Based on 8 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-01-15 · Nutr Diabetes · vol. 11 · issue 1 · p. 6
- Publisher
- Springer Nature
- Cited
- 138 citations · more than 99% of similar papers · 11.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 41 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Enhanced Recovery After Surgery · Diet and metabolism studies
- Keywords
- Obesity, Randomized controlled trial, Medicine, Body weight, Physical therapy, Psychology, Gerontology, Internal medicine
- MeSH
- humans, obesity, body weight, glucose, blood glucose, body mass index, treatment outcome, exercise, diet, reducing, diet, fasting, pilot projects, energy intake, adult, middle aged, female, male, weight reduction programs, meals, snacks
5 authors
From US
- Pamela M. Peeke · correspondingUniversity of Maryland, Baltimore; University of Maryland Extension
- Frank L. GreenwayPennington Biomedical Research Center
- Sonja K. Billes
- Dachuan ZhangPennington Biomedical Research Center
- Ken FujiokaScripps Clinic
Abstract
Background
Time restricted eating (TRE) is an emerging dietary intervention for weight loss that is hypothesized to reinforce the metabolic benefits of nightly fasting/ketosis. This pilot study investigated the effectiveness of a daily 14-h metabolic fast (14:10 TRE beginning after dinner, a "fasting snack" at hour 12, and ending with breakfast 14 h later) combined with a commercial weight management program on body weight and fasting blood glucose (FBG) in individuals with obesity. We also investigated the effect of the low-calorie, high-fat, low-carbohydrate, and low-protein "fasting snack" on blood glucose.
Methods
This 8-week, randomized, controlled, clinical trial included men and women (BMI ≥ 30 kg/m2) between June and October 2020. Study procedures were conducted remotely. Participants were randomized to 14:10 or 12-h TRE (12:12, active comparator) and prescribed a diet (controlled for calories and macronutrient composition) and exercise program that included weekly customized counseling and support. The primary outcome was change from baseline in body weight in the 14:10 group.
Results
Of the 78 randomized participants, 60 (n = 30/group) completed 8 weeks. The LS mean change from baseline in weight in the 14:10 group was -8.5% (95% CI -9.6 to -7.4; P < 0.001) and -7.1% (-8.3 to -5.8; P < 0.001) in the 12:12 group (between group difference -1.4%; -2.7 to -0.2; P < 0.05). There was a statistically significant LS mean change from baseline to week 8 in FBG in the 14:10 group of -7.6 mg/dl (95% CI -15.1 to -0.1; P < 0.05) but not in the 12:12 group (-3.1 mg/dl, -10.0 to 3.7; P = NS). Both interventions resulted in a larger reduction in FBG in participants with elevated FBG (≥100 mg/dl) at baseline (both P < 0.05).
Conclusions
In participants with obesity who completed 8 weeks of the 14:10 TRE schedule combined with a commercial weight loss program, there was statistically significant and clinically meaningful weight loss and improvements in FBG.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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