Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial
Domingues WJR, Ritti-Dias RM, Cucato GG, Wolosker N, Zerati AE, Puech-Leão P, Coelho DB, Nunhes PM, Moliterno AA, Avelar A
Nutrients · 8 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Fundacion Araucaria
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Nonprofit
- Fundação Araucária
- Government
- Fundação de Amparo à Pesquisa do Estado do Amazonas
- Grants
- Fundacion Araucaria (002/2017); Fundação Araucária (#002/2017); Fundação de Amparo à Pesquisa do Estado do Amazonas (#062.03159.2014)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-01-05 · Nutrients · vol. 13 · issue 1 · p. 149
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 11 citations · more than 84% of similar papers · 1.8× the field average
- References
- 41 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Peripheral Artery Disease Management · Musculoskeletal pain and rehabilitation · Muscle metabolism and nutrition
- Keywords
- Medicine, Peripheral, Creatine, Double blind, Arterial disease, Placebo, Randomized controlled trial, Clinical trial, Oxygen metabolism, Oxygen saturation, Double blinded, Internal medicine, Cardiology, Anesthesia, Vascular disease, Oxygen, Chemistry, Pathology
- MeSH
- muscle, skeletal, humans, oxygen, creatine, treatment outcome, pilot projects, comorbidity, oxygen consumption, dietary supplements, aged, middle aged, female, male, peripheral arterial disease, patient outcome assessment, biomarkers
10 authors
From BR, GB
- Wagner Jorge Ribeiro Domingues · correspondingUniversidade Federal do Amazonas
- Raphael Mendes Ritti‐DiasUniversidade Nove de Julho
- Gabriel Grizzo CucatoNorthumbria University
- Nelson WoloskerHospital Israelita Albert Einstein
- Antônio Eduardo ZeratiInstituto do Câncer do Estado de São Paulo
- Pedro Puech‐LeãoUniversidade de São Paulo
Abstract
The aim of the study was to verify the effects of creatine (Cr) supplementation on functional capacity (walking capacity; primary outcome) and calf muscle oxygen saturation (StO2) (secondary outcome) in symptomatic peripheral arterial disease (PAD) patients. Twenty-nine patients, of both sexes, were randomized (1:1) in a double-blind manner for administration of placebo (PLA, n = 15) or creatine monohydrate (Cr, n = 14). The supplementation protocol consisted of 20 g/day for 1 week divided into four equal doses (loading phase), followed by single daily doses of 5 g in the subsequent 7 weeks (maintenance phase). Functional capacity (total walking distance) was assessed by the 6 min walk test, and calf muscle StO2 was assessed through near infrared spectroscopy. The measurements were collected before and after loading and after the maintenance phase. The level of significance was p p = 0.170) and the calf muscle StO2 parameters (p > 0.05). Short- and long-term Cr supplementation does not influence functional capacity and calf muscle StO2 parameters in patients with symptomatic PAD.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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