A positive effect of egg consumption on macular pigment and healthy vision: a systematic review and meta-analysis of clinical trials
Khalighi Sikaroudi M, Saraf-Bank S, Clayton ZS, Soltani S
Journal of the science of food and agriculture · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2021-01-24 · J Sci Food Agric · vol. 101 · issue 10 · pp. 4003–4009
- Publisher
- Wiley
- Cited
- 14 citations · more than 55% of similar papers · 0.7× the field average
- References
- 45 works
- Access
- Paywalled
- Research areas
- Antioxidant Activity and Oxidative Stress · Retinal Diseases and Treatments · Retinoids in leukemia and cellular processes
- Keywords
- Lutein, Zeaxanthin, Macular degeneration, Meta-analysis, Medicine, Clinical trial, Ophthalmology, Randomized controlled trial, Internal medicine, Optical density, Subgroup analysis, Carotenoid, Food science, Biology
- MeSH
- animals, chickens, humans, lutein, eggs, adult, aged, middle aged, female, male, randomized controlled trials as topic, vision, ocular, zeaxanthins, macular pigment
4 authors
From IR, US
- Masoumeh Khalighi SikaroudiIran University of Medical Sciences
- Sahar Saraf‐BankIsfahan University of Medical Sciences
- Zachary Stephen ClaytonUniversity of Colorado Boulder
- Sepideh Soltani · correspondingShahid Sadoughi University of Medical Sciences and Health Services
Abstract
Increasing macular pigment optical density (MPOD) as a result of increased macular concentration of lutein and zeaxanthin may reduce the risk of age-related macular degeneration (AMD). The aim of the present study was to determine whether the consumption of eggs, a rich source of dietary lutein and zeaxanthin, influences MPOD and serum lutein. In this systematic review and meta-analysis we searched PubMed, Scopus, and ISI Web of Science up to July 2020, for relevant randomized clinical trials. Using a random-effects model, pooled weighted mean differences, and standard deviations (SDs) for each outcome were obtained. The quality of the eligible studies was assessed by the Cochrane Collaboration's tool. A meta-analysis of five trials (296 participants) revealed that egg consumption significantly increased MPOD (weighted mean differences (WMD): +0.037; 95% CI: 0.004, 0.069; P = 0.027) and serum lutein (WMD: +0.150 μmol L̂-1; 95% CI: 0.037, 0.263; P = 0.009). Subgroup analyses showed that egg consumption: (a) had a larger effect on MPOD in studies with a parallel design; and (b) increased serum lutein to a greater extent in a healthy population. We did not detect any heterogeneity between studies. Daily egg consumption has beneficial effects on MPOD and serum lutein is inversely associated with reduced AMD progression. Further clinical trials are required to confirm the results of this study. © 2021 Society of Chemical Industry.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.