Antioxidant Activity of Docosahexaenoic Acid (DHA) and Its Regulatory Roles in Mitochondria
Li G, Li Y, Xiao B, Cui D, Lin Y, Zeng J, Li J, Cao MJ, Liu J
Journal of agricultural and food chemistry · 52 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Ministry of Science and Technology of the People's Republic of China
- Government
- Natural Science Foundation of Fujian Province
- Government
- Cultivation Plan for Distinguished Young Scholars in Fujian Universities
- Government
- Ministry of Science and Technology of the People's Republic of China
- Grants
- National Natural Science Foundation of China (42076086); Natural Science Foundation of Fujian Province (2019J05096); Natural Science Foundation of Fujian Province (2017J01447); Ministry of Science and Technology of the People's Republic of China (2018YFD0901004); Natural Science Foundation of Fujian Province (2020J01676); National Natural Science Foundation of China (31771972)
Based on 5 listed funder(s).
Publication
- Published
- 2021-01-26 · J Agric Food Chem · vol. 69 · issue 5 · pp. 1647–1655
- Publisher
- American Chemical Society
- Cited
- 70 citations · more than 92% of similar papers · 2.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Paywalled
- Research areas
- Mitochondrial Function and Pathology · Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress
- Keywords
- Docosahexaenoic acid, Antioxidant, Mitochondrion, Reactive oxygen species, Mitochondrial biogenesis, Biochemistry, Oxidative stress, Oxidative phosphorylation, Chemistry, Biology, Cell biology, Fatty acid, Polyunsaturated fatty acid
- MeSH
- mitochondria, humans, reactive oxygen species, docosahexaenoic acids, antioxidants, cell proliferation, oxidative stress, hep g2 cells
9 authors
From CN
- Guiling Li · correspondingJimei University
- Yuanyuan LiJimei University
- Baoping XiaoJimei University
- Dongyue CuiJimei University
- Yanqi LinJimei University
- Jun ZengJimei University
Abstract
Reactive oxygen species (ROS) are single-electron-bearing oxidation-reduction products that are mainly produced in mitochondria. Excessive ROS accumulation may lead to oxidative damage. Docosahexaenoic acid (DHA) is an essential component of brain phospholipids and is mainly derived from the diet. Its antioxidant activities have been extensively studied. However, its regulatory roles in mitochondria and the underlying mechanism remain to be elucidated. In this study, the DHA's effect on cellular antioxidant capacity and mitochondrial functions was examined in HepG2 cells. The results showed that 100 μM DHA decreased cellular and mitochondrial ROS levels to 75.2 ± 9.4% (P P P P < 0.05), respectively. Furthermore, DHA promoted mitochondrial functions and biogenesis. These data suggested that DHA's antioxidant activity can be attributed to its enhancement of mitochondrial functions and biogenesis. This study may shed light on the molecular mechanisms underlying DHA's function in improving resistance to and relieving the symptoms of chronic disease.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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