Dietary magnesium and migraine in adults: A cross-sectional analysis of the National Health and Nutrition Examination Survey 2001-2004
Slavin M, Li H, Khatri M, Frankenfeld C
Headache · 39 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2021-01-27 · Headache · vol. 61 · issue 2 · pp. 276–286
- Publisher
- Wiley
- Cited
- 50 citations · more than 97% of similar papers · 5.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 45 works
- Access
- Paywalled
- Research areas
- Migraine and Headache Studies · Magnesium in Health and Disease · Folate and B Vitamins Research
- Keywords
- Migraine, National Health and Nutrition Examination Survey, Medicine, Quartile, Odds ratio, Cross-sectional study, Magnesium, Dietary Reference Intake, Reference Daily Intake, Confidence interval, Internal medicine, Environmental health, Nutrient, Population, Chemistry
- MeSH
- humans, magnesium, health surveys, nutrition surveys, cross-sectional studies, eating, dietary supplements, adult, middle aged, united states, female, male, migraine disorders, young adult, recommended dietary allowances
4 authors
From US
- Margaret Slavin · correspondingGeorge Mason University
- Huilun LiGeorge Mason University
- Manisha KhatriGeorge Mason University
- Cara L. FrankenfeldGeorge Mason University
Abstract
Background
Clinical trials have demonstrated magnesium supplements to be effective for prophylactic treatment of migraine. Dietary magnesium intake of many Americans is known to be below nutritional recommendations, but typical magnesium intake from dietary sources in adults with migraine has not previously been evaluated.
Objective
This study aimed to quantify dietary and total (diet + supplement) magnesium consumption of adults with migraine or severe headache in the United States, and to investigate the relationship between magnesium consumption levels and prevalence of migraine or severe headache.
Methods
This analysis included cross-sectional data from 3626 participants, 20- to 50-years old in the National Health and Nutrition Examination Survey between 2001 and 2004. Presence of migraine or severe headache in the past 3 months was determined by questionnaire. Individuals responding affirmatively were classified as having migraine, and individuals reporting not experiencing migraine or severe headache were classified as controls. Dietary magnesium intake was determined from a 24-hour recall interview, supplemental magnesium intake was determined from the dietary supplements interview, and total magnesium intake was the sum of dietary and supplement intake.
Results
Mean dietary consumption of magnesium was below the recommended dietary allowance (RDA) for both migraine (n = 905) and control groups (n = 2721). Attainment of the RDA through a combination of diet and supplements was associated with lower adjusted odds of migraine (odds ratio [OR] = 0.83, 95% confidence intervals [CIs] = 0.70, 0.99, p = 0.035). Magnesium consumption in the highest quartile (Q) was associated with lower odds of migraine than in the lowest Q for both dietary (OR = 0.76, 95% CI = 0.63, 0.92, p = 0.006) and total (OR = 0.78, 95% CI = 0.62, 0.99, p = 0.042) magnesium intake in adjusted models.
Conclusion
These results suggest inadequate consumption of magnesium intake is associated with migraine in U.S. adults ages 20-50. Further prospective investigations are warranted to evaluate the role of dietary magnesium intake on migraine.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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