Ultra-Processed Food Consumption is Associated with Renal Function Decline in Older Adults: A Prospective Cohort Study
Rey-García J, Donat-Vargas C, Sandoval-Insausti H, Bayan-Bravo A, Moreno-Franco B, Banegas JR, Rodríguez-Artalejo F, Guallar-Castillón P
Nutrients · 48 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- Comunidad de Madrid
- Government
- Instituto de Salud Carlos III
- Grants
- Instituto de Salud Carlos III (PI16/); Instituto de Salud Carlos III (PI17/01709); Instituto de Salud Carlos III (FIS PI09/1626, PI16/00609, PI16/01460, PI17/1709, PI20/144); Instituto de Salud Carlos III (FIS PI09/1626); Instituto de Salud Carlos III (PI16/01460); Instituto de Salud Carlos III (PI16/00609); Instituto de Salud Carlos III (PI20/00144)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-01-28 · Nutrients · vol. 13 · issue 2 · p. 428
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 68 citations · more than 98% of similar papers · 8.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 73 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Sodium Intake and Health
- Keywords
- Renal function, Medicine, Prospective cohort study, Confounding, Logistic regression, Creatinine, Cohort, Internal medicine, Odds ratio, Cohort study
- MeSH
- kidney, humans, kidney function tests, confidence intervals, odds ratio, risk factors, prospective studies, feeding behavior, energy intake, aged, female, male, fast foods
8 authors
From ES, SE, US
- Jimena Rey-GarcíaInstituto Cajal; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universidad Autónoma de Madrid
- Carolina Donat‐Vargas · correspondingMadrid Institute for Advanced Studies; Karolinska Institutet; IMDEA Food; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universidad Autónoma de Madrid
- Helena Sandoval‐InsaustiHarvard University; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universidad Autónoma de Madrid
- Ana Bayán-BravoResearch Institute Hospital 12 de Octubre
- Belén Moreno‐FrancoUniversidad de Zaragoza; Hospital Universitario Miguel Servet; Instituto de Investigación Sanitaria Aragón
- José R. BanegasCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universidad Autónoma de Madrid
Abstract
Ultra-processed food (UPF) consumption has been associated with increased risk of cardiovascular risk factors and mortality. However, little is known on the UPF effect on renal function. The aim of this study is to assess prospectively the association between consumption of UPF and renal function decline. This is a prospective cohort study of 1312 community-dwelling individuals aged 60 and older recruited during 2008-2010 and followed up to December 2015. At baseline, a validated dietary history was obtained. UPF was identified according to NOVA classification. At baseline and at follow-up, serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) levels were ascertained and changes were calculated. A combined end-point of renal decline was considered: SCr increase or eGFR decreased beyond that expected for age. Logistic regression with adjustment for potential confounders was performed. During follow-up, 183 cases of renal function decline occurred. The fully adjusted odds ratios (95% CI) of renal function decline across terciles of percentage of total energy intake from UPF were 1.56 (1.02-2.38) for the second tercile, and 1.74 (1.14-2.66) for the highest tercile; p-trend was 0.026. High UPF consumption is independently associated with an increase higher than 50% in the risk of renal function decline in Spanish older adults.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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