Creatine in Health and Disease
Kreider RB, Stout JR
Nutrients · 155 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People, plus animal or lab work
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Authors
- At least one author declares a financial tie to industry
Based on full-text disclosure statement.
Publication
- Published
- 2021-01-29 · Nutrients · vol. 13 · issue 2 · p. 447
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 226 citations · more than 100% of similar papers · 12.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 357 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Muscle metabolism and nutrition · Diet and metabolism studies · High Altitude and Hypoxia
- Keywords
- Creatine, Disease, Medicine, Physiology, Intensive care medicine, Physical therapy, Internal medicine
- MeSH
- humans, wounds and injuries, chronic disease, creatine, biological availability, aging, dietary supplements
2 authors
From US
- Richard B. Kreider · correspondingTexas A&M University
- Jeffrey R. StoutUniversity of Central Florida
Abstract
Although creatine has been mostly studied as an ergogenic aid for exercise, training, and sport, several health and potential therapeutic benefits have been reported. This is because creatine plays a critical role in cellular metabolism, particularly during metabolically stressed states, and limitations in the ability to transport and/or store creatine can impair metabolism. Moreover, increasing availability of creatine in tissue may enhance cellular metabolism and thereby lessen the severity of injury and/or disease conditions, particularly when oxygen availability is compromised. This systematic review assesses the peer-reviewed scientific and medical evidence related to creatine's role in promoting general health as we age and how creatine supplementation has been used as a nutritional strategy to help individuals recover from injury and/or manage chronic disease. Additionally, it provides reasonable conclusions about the role of creatine on health and disease based on current scientific evidence. Based on this analysis, it can be concluded that creatine supplementation has several health and therapeutic benefits throughout the lifespan.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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