Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old
Melo van Lent D, Egert S, Wolfsgruber S, Kleineidam L, Weinhold L, Wagner-Thelen H, Maier W, Jessen F, Ramirez A, Schmid M, Scherer M, Riedel-Heller SG, Wagner M
Nutrients · 29 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Alzheimer Forschung Initiative
- Government
- Bundesministerium für Bildung und Forschung
- Grants
- Bundesministerium für Bildung und Forschung (01GI0102); Bundesministerium für Bildung und Forschung (01EA1372D); Bundesministerium für Bildung und Forschung (01GY1322D); Bundesministerium für Bildung und Forschung (01GI0715); Bundesministerium für Bildung und Forschung (01GI0429); Bundesministerium für Bildung und Forschung (01GI0434); Bundesministerium für Bildung und Forschung (01GI0423); Bundesministerium für Bildung und Forschung (01GI0422); Bundesministerium für Bildung und Forschung (01GY1322A, 01GY1322B, 01GY1322C, 01GY1322D, 01GY1322E, 01GY1322F, 01GY1322G); Bundesministerium für Bildung und Forschung (01GY1322B); Bundesministerium für Bildung und Forschung (01GY1322C); Bundesministerium für Bildung und Forschung (01EA1410C); Bundesministerium für Bildung und Forschung (01GI0712); Bundesministerium für Bildung und Forschung (01GY1322F); Bundesministerium für Bildung und Forschung (01GI0711); Bundesministerium für Bildung und Forschung (01GI0716); Bundesministerium für Bildung und Forschung (01GI0431); Bundesministerium für Bildung und Forschung (01GI0713); Bundesministerium für Bildung und Forschung (01GI0420); Bundesministerium für Bildung und Forschung (01GI0710); Bundesministerium für Bildung und Forschung (01GI0714); Bundesministerium für Bildung und Forschung (01GY1322E); Bundesministerium für Bildung und Forschung (01GI0433); Bundesministerium für Bildung und Forschung (01GY1322G); Bundesministerium für Bildung und Forschung (01GI0710, 01GI0711, 01GI0712, 01GI0713, 01GI0714, 01GI0715, 01GI0716); Bundesministerium für Bildung und Forschung (01GY1322A)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-01-30 · Nutrients · vol. 13 · issue 2 · p. 461
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 43 citations · more than 92% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 70 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Fatty Acid Research and Health · Nutritional Studies and Diet · Eicosanoids and Hypertension Pharmacology
- Keywords
- Eicosapentaenoic acid, Dementia, Docosahexaenoic acid, Polyunsaturated fatty acid, Arachidonic acid, Medicine, Internal medicine, Hazard ratio, Cognitive decline, Linoleic acid, Omega 3 fatty acid, Vascular dementia, Gastroenterology, Fatty acid, Disease, Biochemistry, Biology, Confidence interval
- MeSH
- humans, dementia, alzheimer disease, fatty acids, omega-3, eicosapentaenoic acid, fatty acids, fatty acids, unsaturated, fatty acids, omega-6, phospholipids, activities of daily living, incidence, proportional hazards models, longitudinal studies, prospective studies, aged, 80 and over, germany, female, male
13 authors
From US, DE
- Debora Melo van Lent · correspondingThe University of Texas at San Antonio Health Science Center; German Center for Neurodegenerative Diseases; Institute for Neurodegenerative Disorders
- Sarah EgertUniversity of Hohenheim
- Steffen WolfsgruberUniversity Hospital Bonn; German Center for Neurodegenerative Diseases
- Luca KleineidamUniversity Hospital Bonn
- Leonie WeinholdUniversity Hospital Bonn; Zimmer Biomet (Germany)
- Holger Wagner-ThelenUniversity Hospital Bonn
Abstract
Background
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) may have different effects on cognitive health due to their anti- or pro-inflammatory properties.
Methods
We aimed to prospectively examine the relationships between n-3 and n-6 PUFA contents in serum phospholipids with incident all-cause dementia and Alzheimer's disease dementia (AD). We included 1264 non-demented participants aged 84 ± 3 years from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe) multicenter-cohort study. We investigated whether fatty acid concentrations in serum phospholipids, especially eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), dihomo-γ-linolenic acid (DGLA), and arachidonic acid (AA), were associated with risk of incident all-cause dementia and AD.
Results
During the follow-up window of seven years, 233 participants developed dementia. Higher concentrations of EPA were associated with a lower incidence of AD (hazard ratio (HR) 0.76 (95% CI 0.63; 0.93)). We also observed that higher concentrations of EPA were associated with a decreased risk for all-cause dementia (HR 0.76 (95% CI 0.61; 0.94)) and AD (HR 0.66 (95% CI 0.51; 0.85)) among apolipoprotein E ε4 (APOE ε4) non-carriers but not among APOE ε4 carriers. No other fatty acids were significantly associated with AD or dementia.
Conclusions
Higher concentrations of EPA were associated with a lower risk of incident AD. This further supports a beneficial role of n-3 PUFAs for cognitive health in old age.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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