Usefulness of Extra Virgin Olive Oil Minor Polar Compounds in the Management of Chronic Kidney Disease Patients
Noce A, Marrone G, Urciuoli S, Di Daniele F, Di Lauro M, Pietroboni Zaitseva A, Di Daniele N, Romani A
Nutrients · 38 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Regione Toscana
Based on 1 listed funder(s).
Publication
- Published
- 2021-02-10 · Nutrients · vol. 13 · issue 2 · p. 581
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 49 citations · more than 95% of similar papers · 3.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 84 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Edible Oils Quality and Analysis · Nutritional Studies and Diet · Fatty Acid Research and Health
- Keywords
- Medicine, Renal function, Kidney disease, Oxidative stress, Albuminuria, Internal medicine, Uric acid, Azotemia, Endocrinology, Physiology, Food science, Chemistry
- MeSH
- humans, albuminuria, inflammation, phenylethyl alcohol, aldehydes, phenols, uric acid, c-reactive protein, antioxidants, glomerular filtration rate, body composition, oxidative stress, diet, mediterranean, aged, aged, 80 and over, middle aged, female, male, renal insufficiency, chronic, azotemia, polyphenols, biomarkers, olive oil, surveys and questionnaires, cyclopentane monoterpenes
8 authors
From IT
- Annalisa Noce · correspondingUniversity of Rome Tor Vergata
- Giulia MarroneUniversity of Rome Tor Vergata
- Silvia UrciuoliUniversity of Florence
- Francesca Di DanieleUniversity of Rome Tor Vergata
- Manuela Di LauroUniversity of Rome Tor Vergata
- Anna Pietroboni ZaitsevaUniversity of Rome Tor Vergata
Abstract
Chronic kidney disease (CKD) is one of the most common chronic non-communicable degenerative diseases and it represents an important risk factor for cardiovascular morbidity and mortality. The Mediterranean diet, in which extra virgin olive oil (EVOO) is the main source of vegetal fats, represents a nutritional-diet regimen that is useful for the treatment of CKD and its comorbidities. We tested two different EVOOs, characterized by a high (Synergy) and medium (Luxolio) content of minor polar compounds (MPCs), detected by HPLC-DAD-MS analysis, in 40 nephropathic patients, at a dose of 40 mL/day for 9 weeks. We evaluated the effects of these two EVOOs on renal function, body composition, oxidative stress, and inflammatory state, after 9 weeks of EVOOs consumption (T1) and after 2 months of wash-out (T2). We observed an improvement of renal function biomarkers (estimated-glomerular filtration rate, albuminuria, azotemia, uric acid), lipid profile, oxidative stress, inflammatory parameters (erythrocyte sedimentation rate, C-reactive protein) and in body composition at T1. These healthy effects were greater and persisted over time after the wash-out period in Synergy patients. The high MPC EVOO content seems to exert an antioxidant and anti-inflammatory effect in nephropathic patients and these protective actions are maintained over time.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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