Impact of Intermittent Fasting on Lipid Profile-A Quasi-Randomized Clinical Trial
Ahmed N, Farooq J, Siddiqi HS, Meo SA, Kulsoom B, Laghari AH, Jamshed H, Pasha F
Frontiers in nutrition · 25 citations
How it was studied
- Design
- Case report (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- King Saud University
- Grants
- King Saud University (RSP-2019/47); King Saud University (RSP‐2019)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-01-31 · Front Nutr · vol. 7 · p. 596787
- Publisher
- Frontiers Media
- Cited
- 50 citations · more than 95% of similar papers · 4.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 25 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Diet, Metabolism, and Disease
- Keywords
- Waist, Medicine, Lipid profile, Internal medicine, Randomized controlled trial, Blood pressure, Cholesterol, Weight loss, Blood lipids, Circumference, Body mass index, Endocrinology, Obesity
8 authors
From PK, SA, US
- Naseer Ahmed · correspondingAga Khan University
- Javeria FarooqAga Khan University
- Hasan Salman SiddiqiAga Khan University
- Sultan Ayoub MeoKing Saud University
- Bibi KulsoomBahria University
- Abid Hussain LaghariAga Khan University
Abstract
Background: Sub-optimal HDL is a prognostic marker of cardiovascular disease. South Asia has a high prevalence of sub-optimal HDL compared to other parts of the world. Intermittent fasting (IF) is a type of energy restriction which may improve serum HDL and other lipids thereby reducing the risk of cardiovascular diseases. Objective: The aim of the study was to evaluate the effect of IF on lipid profile and HDL-cholesterol in a sample of South Asian adults. Methods: A 6-week quasi-experimental (non-randomized) clinical trial was conducted on participants with low HDL (Result: A total of 40 participants were enrolled in the study (N = 20 in each group), while 35 (20 control and 15 intervention) completed the trial and were included in data analysis of the study. Body measurements, including body weight, BMI and waist circumference, showed significant interaction effects (p's p = 0.033), HDL (p = 0.0001), and LDL cholesterol (p = 0.010) with larger improvements in the IF group. Conclusion: This study suggests that intermittent fasting may protect cardiovascular health by improving the lipid profile and raising the sub-optimal HDL. Intermittent fasting may be adopted as a lifestyle intervention for the prevention, management and treatment of cardiovascular disorders. Clinical Trial Registration: NCT03805776, registered on January 16, 2019, https://clinicaltrials.gov/ct2/show/NCT03805776.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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