Magnesium intake, insulin resistance and markers of endothelial function among women
Bavani NG, Saneei P, Hassanzadeh Keshteli A, Yazdannik A, Falahi E, Sadeghi O, Esmaillzadeh A
Public health nutrition · 10 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Isfahan University of Medical Sciences
- University or hospital
- Lorestan University of Medical Sciences
- University or hospital
- Food Security Research Center, Isfahan University of Medical Sciences
Based on 3 listed funder(s).
Publication
- Published
- 2021-03-15 · Public Health Nutr · vol. 24 · issue 17 · pp. 5777–5785
- Publisher
- Cambridge University Press
- Cited
- 14 citations · more than 72% of similar papers · 1.0× the field average
- References
- 49 works
- Access
- Free to read
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Keywords
- Insulin resistance, Insulin sensitivity, Magnesium, Function (biology), Insulin, Linkage (software)
- MeSH
- humans, insulin resistance, magnesium, insulin, blood glucose, cross-sectional studies, iran, female, biomarkers
7 authors
From IR, CA
- Narges Ghorbani BavaniIsfahan University of Medical Sciences
- Parvane SaneeiIsfahan University of Medical Sciences
- Ammar Hassanzadeh KeshteliUniversity of Alberta
- Ahmadreza YazdannikIsfahan University of Medical Sciences; Iranshahr University
- Ebrahim FalahiLorestan University of Medical Sciences
- Omid SadeghiTehran University of Medical Sciences
Abstract
Objective
We investigated the association of dietary Mg intake with insulin resistance and markers of endothelial function among Iranian women.
Design
A cross-sectional study.
Setting
Usual dietary intakes were assessed using a validated FFQ. Dietary Mg intake was calculated by summing up the amount of Mg in all foods. A fasting blood sample was taken to measure serum concentrations of glycemic indices (fasting plasma glucose and insulin) and endothelial function markers (E-selectin, soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1). Insulin resistance and sensitivity were estimated using the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), Homeostasis Model Assessment β-cell function (HOMA-β) and quantitative insulin sensitivity check index (QUICKI).
Participants
Iranian female nurses (n 345) selected by a multistage cluster random sampling method.
Results
The Mg intake across energy-adjusted quartiles was 205 (se 7), 221·4 (se 8), 254·3 (se 7) and 355·2 (se 9) mg/d, respectively. After adjustments for potential confounders, QUICKI level was significantly different across quartiles of Mg intake (Q1: 0·34 (se 0·02), Q2: 0·36 (se 0·01), Q3: 0·40 (se 0·01), and Q4: 0·39 (se 0·02), P = 0·02); however, this association disappeared after considering markers of endothelial function, indicating that this relation might be mediated through endothelial dysfunction. After controlling for all potential confounders, Mg intake was inversely, but not significantly, associated with serum concentrations of sICAM (Q1: 239 (se 17), Q2: 214 (se 12), Q3: 196 (se 12), and Q4: 195 (se 17), P = 0·29). There was no other significant association between dietary Mg intake and other indicators of glucose homoeostasis or endothelial markers.
Conclusions
Higher dietary Mg intake was associated with better insulin sensitivity in Iranian females. This linkage was mediated through reduced endothelial dysfunction.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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