Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration
Kozłowska M, Kortas J, Żychowska M, Antosiewicz J, Żuczek K, Perego S, Lombardi G, Ziemann E
Scientific reports · 13 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Science Centre OPUS 13
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-03-29 · Sci Rep · vol. 11 · issue 1 · p. 7097
- Publisher
- Nature Portfolio
- Cited
- 20 citations · more than 83% of similar papers · 1.6× the field average
- References
- 76 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Adipose Tissue and Metabolism · Exercise and Physiological Responses · Fibroblast Growth Factor Research
- Keywords
- Myostatin, Internal medicine, Endocrinology, Myokine, Adiponectin, Glucose homeostasis, Valine, Hyperinsulinemia, Medicine, Homeostasis, Insulin, Insulin resistance, Biology, Amino acid, Muscle hypertrophy, Skeletal muscle, Biochemistry
- MeSH
- humans, glucose, amino acids, cryotherapy, homeostasis, adult, female, male, myostatin, young adult
8 authors
From PL, IT
- Marta KozłowskaGdansk University of Physical Education and Sport
- Jakub Antoni KortasGdansk University of Physical Education and Sport
- Małgorzata ŻychowskaKazimierz Wielki University in Bydgoszcz
- Jędrzej AntosiewiczGdańsk Medical University
- Klaudia ŻuczekGdańsk Medical University
- Silvia PeregoIRCCS Ospedale Galeazzi - Sant'Ambrogio; Istituti di Ricovero e Cura a Carattere Scientifico
Abstract
The study investigated the effect of single and chronic (10 sessions) whole-body cryotherapy (WBC; 3-min, - 110 °C) on amino acid (AA) profile, myostatin, fibroblast growth factor 21 (FGF21), and concentrations of brain-derived neurotrophic factor (BDNF), irisin and adiponectin in relation to glucose homeostasis. Thirty-five, healthy men were randomly split into experimental (young: 28 ± 7 years and middle-aged: 51 ± 3 years) and control groups. Blood samples were taken before and 1 h after the first and last (10th) WBC session. Baseline myostatin correlated significantly with visceral fat area, glucose, insulin, HOMA-IR and irisin (all p < 0.05). The single session of WBC induced temporary changes in AA profile, whereas chronic exposure lowered valine and asparagine concentrations (p < 0.01 and p = 0.01, respectively) compared to the baseline. The chronic WBC reduced fasting glucose (p = 0.04), FGF21 (- 35.8%, p = 0.06) and myostatin (-18.2%, p = 0.06). Still, the effects were age-dependent. The decrease of myostatin was more pronounced in middle-aged participants (p < 0.01). Concentrations of irisin and adiponectin increased in response to chronic WBC, while BDNF level remained unchanged. By improving the adipo-myokine profile, chronic WBC may reduce effectively the risk of the metabolic syndrome associated with hyperinsulinemia, increased levels of valine and asparagine, and muscle atrophy.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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