Experimental and Clinical Applications of Red and Near-Infrared Photobiomodulation on Endothelial Dysfunction: A Review
Colombo E, Signore A, Aicardi S, Zekiy A, Utyuzh A, Benedicenti S, Amaroli A
Biomedicines · 48 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2021-03-09 · Biomedicines · vol. 9 · issue 3 · p. 274
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 83 citations · more than 98% of similar papers · 7.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 105 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Laser Applications in Dentistry and Medicine · Medical and Biological Ozone Research · Infrared Thermography in Medicine
- Keywords
- Endothelial dysfunction, Homeostasis, Angiogenesis, In vivo, Medicine, Vasodilation, Inflammation, Bioinformatics, Pharmacology, Internal medicine, Biology, Biotechnology
7 authors
From IT, RU
- Esteban ColomboUniversity of Genoa
- Antonio SignoreSechenov University; University of Genoa
- Stefano AicardiUniversity of Genoa
- Angelina Olegovna ZekiySechenov University
- Anatoliy S. UtyuzhSechenov University
- Stefano BenedicentiUniversity of Genoa
Abstract
Background
Under physiological conditions, endothelial cells are the main regulator of arterial tone homeostasis and vascular growth, sensing and transducing signals between tissue and blood. Disease risk factors can lead to their unbalanced homeostasis, known as endothelial dysfunction. Red and near-infrared light can interact with animal cells and modulate their metabolism upon interaction with mitochondria's cytochromes, which leads to increased oxygen consumption, ATP production and ROS, as well as to regulate NO release and intracellular Ca2+ concentration. This medical subject is known as photobiomodulation (PBM). We present a review of the literature on the in vitro and in vivo effects of PBM on endothelial dysfunction.
Methods
A search strategy was developed consistent with the PRISMA statement. The PubMed, Scopus, Cochrane, and Scholar electronic databases were consulted to search for in vitro and in vivo studies.
Results
Fifty out of >12,000 articles were selected.
Conclusions
The PBM can modulate endothelial dysfunction, improving inflammation, angiogenesis, and vasodilatation. Among the studies, 808 nm and 18 J (0.2 W, 2.05 cm2) intracoronary irradiation can prevent restenosis as well as 645 nm and 20 J (0.25 W, 2 cm2) can stimulate angiogenesis. PBM can also support hypertension cure. However, more extensive randomised controlled trials are necessary.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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