Time-Restricted Eating for 12 Weeks Does Not Adversely Alter Bone Turnover in Overweight Adults
Lobene AJ, Panda S, Mashek DG, Manoogian ENC, Hill Gallant KM, Chow LS
Nutrients · 24 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Indiana Clinical and Translational Sciences Institute
- University or hospital
- Healthy Foods, Healthy Lives Institute, University of Minnesota
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Center for Advancing Translational Sciences
- Government
- NCATS NIH HHS
- Government
- NIDDK NIH HHS
- Grants
- National Center for Advancing Translational Sciences (TL1 TR002531); National Center for Advancing Translational Sciences (UL1TR002529); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK124484); Indiana Clinical and Translational Sciences Institute (TL1 TR002531); National Center for Advancing Translational Sciences ((UL1-TR002494)); Indiana Clinical and Translational Sciences Institute (UL1TR002529); Indiana Clinical and Translational Sciences Institute (UL1TR002529, TL1TR002531); National Institute of Diabetes and Digestive and Kidney Diseases (K01DK102864); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK118278); Healthy Foods, Healthy Lives Institute, University of Minnesota (17SFR-2YR50LC)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-03-31 · Nutrients · vol. 13 · issue 4 · p. 1155
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 26 citations · more than 86% of similar papers · 2.0× the field average
- References
- 55 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Circadian rhythm and melatonin
- Keywords
- Bone remodeling, Overweight, Endocrinology, Internal medicine, Medicine, N-terminal telopeptide, Bone mineral, Parathyroid hormone, Weight loss, Turnover, Bone resorption, Obesity, Osteoporosis, Chemistry, Calcium, Osteocalcin
- MeSH
- bone and bones, humans, feeding behavior, bone density, time factors, adult, middle aged, female, male, overweight, biomarkers
6 authors
From US
- Andrea J. Lobene · correspondingPurdue University West Lafayette; University of Delaware
- Satchidananda PandaSalk Institute for Biological Studies
- Douglas G. MashekUniversity of Minnesota
- Emily N. C. ManoogianSalk Institute for Biological Studies
- Kathleen M. Hill GallantUniversity of Minnesota; Purdue University West Lafayette
- Lisa Senye ChowUniversity of Minnesota
Abstract
Weight loss is a major focus of research and public health efforts. Time-restricted eating (TRE) is shown to be effective for weight loss, but the impact on bone is unclear. Short-term TRE studies show no effect on bone mineral density (BMD), but no study has measured bone turnover markers. This secondary analysis examined the effect of 12 weeks of TRE vs. unrestricted eating on bone turnover and BMD. Overweight and obese adults aged 18-65 y (n = 20) were randomized to TRE (ad libitum 8-h eating window) or non-TRE. Serum N-terminal propeptide of type I collagen (P1NP), cross-linked N-telopeptide of type I collagen (NTX), and parathyroid hormone (PTH) levels were measured and dual-energy X-ray absorptiometry (DXA) scans were taken pre- and post-intervention. In both groups, P1NP decreased significantly (p = 0.04) but trended to a greater decrease in the non-TRE group (p = 0.07). The treatment time interaction for bone mineral content (BMC) was significant (p = 0.02), such that BMC increased in the TRE group and decreased in the non-TRE group. Change in P1NP was inversely correlated with change in weight (p = 0.04) overall, but not within each group. These findings suggest that TRE does not adversely affect bone over a moderate timeframe. Further research should examine the long-term effects of TRE on bone.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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