Red meat consumption, cooking mutagens, NAT1/2 genotypes and pancreatic cancer risk in two ethnically diverse prospective cohorts
Huang BZ, Wang S, Bogumil D, Wilkens LR, Wu L, Blot WJ, Zheng W, Shu XO, Pandol SJ, Le Marchand L, Setiawan VW
International journal of cancer · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Nonprofit
- American Cancer Society
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (K99CA256525); National Cancer Institute (R01 CA209798); National Cancer Institute (U01 CA164973); National Cancer Institute (U01‐CA202979); American Cancer Society (RSG-16-250-01-CPHPS); National Cancer Institute (P01 CA236585); National Cancer Institute (T32CA229110); National Institutes of Health (U01 CA 202979); National Institutes of Health (U01CA164973); National Institutes of Health (R01CA209798); National Institutes of Health (T32CA229110)
Based on 4 listed funder(s).
Publication
- Published
- 2021-04-12 · Int J Cancer · vol. 149 · issue 4 · pp. 811–819
- Publisher
- Wiley
- Cited
- 18 citations · more than 82% of similar papers · 1.2× the field average
- References
- 38 works
- Access
- Free to read
- Research areas
- Pancreatic and Hepatic Oncology Research · Cancer Risks and Factors · Colorectal Cancer Screening and Detection
- Keywords
- Pancreatic cancer, Medicine, Red meat, Prospective cohort study, Cohort study, Cohort, Internal medicine, Cancer, Relative risk, Genotype, Proportional hazards model, Confidence interval, Biology, Pathology, Genetics, Gene
11 authors
From US
- Brian Z. Huang · correspondingUniversity of Southern California; Kaiser Permanente
- Songren WangUniversity of Southern California
- David Daniel BogumilUniversity of Southern California
- Lynne Ross WilkensUniversity of Hawaiʻi at Mānoa; University of Hawaii System; Cancer Center of Hawaii; University of Hawaii Cancer Center
- Lang WuUniversity of Hawaiʻi at Mānoa; University of Hawaii System; Cancer Center of Hawaii; University of Hawaii Cancer Center
- William J. BlotVanderbilt University Medical Center
Abstract
There is limited evidence on the association between red meat consumption and pancreatic cancer among ethnic minorities. We assessed this relationship in two large prospective cohorts: the Multiethnic Cohort Study (MEC) and the Southern Community Cohort Study (SCCS). Demographic, dietary and other risk factor data were collected at cohort entry. Red meat intake was assessed using cohort-specific validated food frequency questionnaires. Incident pancreatic cancer cases were identified via linkages to state cancer registries. Cox regression was used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for the association of red meat intake with pancreatic cancer risk in each cohort. We performed additional analyses to evaluate cooking methods, mutagens and effect modification by NAT1/2 genotypes. From a total of 184 542 (MEC) and 66 793 (SCCS) at-risk participants, we identified 1618 (MEC) and 266 (SCCS) incident pancreatic cancer cases. Red meat consumption was associated with pancreatic cancer risk in the MEC (RRQ4vsQ1 1.18, 95% CI 1.02-1.37) and with borderline statistical significance in the SCCS (RRQ4vsQ1 1.31, 95% CI 0.93-1.86). This association was significant in African Americans (RRQ4vsQ1 1.49, 95% CI 1.06-2.11) and Latinos (RRQ4vsQ1 1.44, 95% CI 1.02-2.04) in the MEC, and among African Americans (RRQ4vsQ1 1.55, 95% CI 1.03-2.33) in the SCCS. NAT2 genotypes appeared to modify the relationship between red meat and pancreatic cancer in the MEC (pinteraction = 0.03). Our findings suggest that the associations for red meat may be strongest in African Americans and Latinos. The mechanisms underlying the increased risk for these populations should be further investigated.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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