Inter-Individual Variation in Postprandial Glycemic Responses in Women Co-Ingesting Green Leafy Vegetables with a Carbohydrate Meal: Interactions with the Sirtuin System
Sayegh M, Henderson J, Farquharson AJ, Horgan G, Ranawana V, Drew JE
Molecular nutrition & food research · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- Rural and Environment Science and Analytical Services Division
- Government
- Scottish Government
- University or hospital
- University of Aberdeen
Based on 3 listed funder(s).
Publication
- Published
- 2021-04-15 · Mol Nutr Food Res · vol. 65 · issue 13 · p. e2000923
- Publisher
- Wiley
- Cited
- 4 citations · more than 55% of similar papers · 0.4× the field average
- References
- 40 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Sirtuins and Resveratrol in Medicine · Adipose Tissue and Metabolism · Nuts composition and effects
- Keywords
- Postprandial, Glycemic, Meal, Leafy vegetables, Sirtuin, Food science, Glycemic load, Carbohydrate, Glycemic index, Biology, Medicine, Internal medicine, Endocrinology, Diabetes mellitus, Biochemistry
- MeSH
- humans, vegetables, insulin, sirtuins, dietary carbohydrates, blood glucose, lipids, intercellular signaling peptides and proteins, gene expression profiling, postprandial period, adult, aged, middle aged, female, young adult
6 authors
From GB
- Marietta SayeghUniversity of Aberdeen
- Jaye HendersonUniversity of Aberdeen
- Andrew J. FarquharsonUniversity of Aberdeen
- Graham William HorganUniversity of Aberdeen; Biomathematics and Statistics Scotland
- Viren RanawanaUniversity of Aberdeen
- Janice E. Drew · correspondingUniversity of Aberdeen
Abstract
Scope
Green leafy vegetables (GLV) may improve postprandial glycemic responses (PGR) and metabolic health. However, inter-individual variations (IIV) preclude conclusive evidence. Sirtuin system is emerging as a key player in blood glucose control. This study investigates IIV in PGR in women co-ingesting GLV with a carbohydrate meal and interactions with the sirtuin system.
Methods and results
Volunteers (n = 31 women) consume rice, rice with bok choy, or spinach (75g available carbohydrate) on separate occasions. Postprandial glucose, insulin, adropin, and lipid levels are measured. Anthropometric measurements and sex hormones are measured. GeXP assay measures whole blood postprandial gene expression profiles of 25 markers involved in sirtuin signaling. GLV consumption has no significant effect on PGR, which shows high variation. PGR correlated with age, but no other consistent associations are observed. Sirtuin gene expression profiles reveal distinct stratified subgroups associated with PGR, lipid, insulin, fat mass, waist/hip circumferences, and adropin levels.
Conclusion
PGR to co-ingesting GLV with a carbohydrate meal are highly variable in this cohort and fail to reveal a significant reduction in PGR. Variable responses are largely independent of menopausal status and meal consumed. However, lower expression of sirtuin gene targets is associated with higher PGR and with markers linked to health status.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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