The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial
Hemamy M, Pahlavani N, Amanollahi A, Islam SMS, McVicar J, Askari G, Malekahmadi M
BMC pediatrics · 40 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Isfahan University of Medical Sciences
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-04-17 · BMC Pediatr · vol. 21 · issue 1 · p. 178
- Publisher
- BioMed Central
- Cited
- 60 citations · more than 96% of similar papers · 4.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Attention Deficit Hyperactivity Disorder · Children's Physical and Motor Development · Bipolar Disorder and Treatment
- Keywords
- Medicine, Placebo, Randomized controlled trial, Vitamin D and neurology, Attention deficit hyperactivity disorder, Vitamin, Mental health, Internal medicine, Magnesium, Pediatrics, Psychiatry
- MeSH
- humans, magnesium, vitamin d, double-blind method, attention deficit disorder with hyperactivity, health status, dietary supplements, child
7 authors
From IR, AU
- Mostafa HemamyIsfahan University of Medical Sciences
- Naseh PahlavaniKurdistan University of Medical Sciences; Gonabad University of Medical Sciences
- Alireza AmanollahiShahid Beheshti University of Medical Sciences
- Sheikh Mohammed Shariful IslamDeakin University
- Jenna McVicarDeakin University
- Gholamreza Askari · correspondingIsfahan University of Medical Sciences
Abstract
Background
Attention-Deficit / Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder, characterized by varying severity in attention deficit and hyperactivity. Studies have shown deficiencies in the serum level of magnesium and vitamin D in people with ADHD. The aim of this study is to determine the effect of vitamin D and magnesium supplementation on mental health in children with ADHD.
Methods
We conducted a randomized, double blind, placebo-controlled clinical trial of 66 children with ADHD. Participants were randomly allocated to receive both vitamin D (50,000 IU/week) plus magnesium (6 mg/kg/day) supplements (n = 33) or placebos (n = 33) for 8-weeks. Strengths and difficulties questionnaire was used to evaluate children's mental health at baseline and the end of the study.
Results
After eight weeks of intervention, the serum levels of 25-hydroxy-vitamin D3 and magnesium increased significantly in the intervention group compared with the control group. Also, children receiving vitamin D plus magnesium showed a significant reduction in emotional problems (p = 0.001), conduct problems (p = 0.002), peer problems (p = 0.001), prosocial score (p = 0.007), total difficulties (p = 0.001), externalizing score (p = 0.001), and internalizing score (p = 0.001) compared with children treated with the placebo.
Conclusion
Vitamin D (50,000 IU/week) and magnesium (6 mg/kg/day) co-supplementation for a duration of 8-weeks could improve the behavioral function and mental health of children with ADHD. However, further well-designed studies with a larger sample size are needed.
Trial registration
IRCT2016030326886N1 .
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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