Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis
Mah J, Pitre T
BMC complementary medicine and therapies · 36 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- London School of Hygiene and Tropical Medicine
- University or hospital
- Dalhousie University
- Nonprofit
- Killam Trusts
- Government
- Research Nova Scotia
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-04-17 · BMC Complement Med Ther · vol. 21 · issue 1 · p. 125
- Publisher
- BioMed Central
- Cited
- 54 citations · more than 82% of similar papers · 1.5× the field average
- References
- 23 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Sleep and related disorders · Restless Legs Syndrome Research
- Keywords
- Medicine, Placebo, Randomized controlled trial, Insomnia, Meta-analysis, Adverse effect, MEDLINE, Clinical trial, Physical therapy, Sleep onset latency, Internal medicine, Sleep disorder, Alternative medicine, Psychiatry
- MeSH
- humans, sleep initiation and maintenance disorders, magnesium, phytotherapy, dietary supplements, aged, female, male
2 authors
From CA
- Jasmine Cassy Mah · correspondingDalhousie University
- Tyler PitreRegional Municipality of Waterloo; McMaster University
Abstract
Background
Magnesium supplementation is often purported to improve sleep; however, as both an over-the-counter sleep aid and a complementary and alternative medicine, there is limited evidence to support this assertion. The aim was to assess the effectiveness and safety of magnesium supplementation for older adults with insomnia.
Methods
A search was conducted in MEDLINE, EMBASE, Allied and Complementary Medicine, clinicaltrials.gov and two grey literature databases comparing magnesium supplementation to placebo or no treatment. Outcomes were sleep quality, quantity, and adverse events. Risk of bias and quality of evidence assessments were carried out using the RoB 2.0 and Grading of Recommendations Assessment, Development and Evaluation (GRADE) approaches. Data was pooled and treatment effects were quantified using mean differences. For remaining outcomes, a modified effects direction plot was used for data synthesis.
Results
Three randomized control trials (RCT) were identified comparing oral magnesium to placebo in 151 older adults in three countries. Pooled analysis showed that post-intervention sleep onset latency time was 17.36 min less after magnesium supplementation compared to placebo (95% CI - 27.27 to - 7.44, p = 0.0006). Total sleep time improved by 16.06 min in the magnesium supplementation group but was statistically insignificant. All trials were at moderate-to-high risk of bias and outcomes were supported by low to very low quality of evidence.
Conclusion
This review confirms that the quality of literature is substandard for physicians to make well-informed recommendations on usage of oral magnesium for older adults with insomnia. However, given that oral magnesium is very cheap and widely available, RCT evidence may support oral magnesium supplements (less than 1 g quantities given up to three times a day) for insomnia symptoms.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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