Psychotherapy with Music Intervention Improves Anxiety, Depression and the Redox Status in Breast Cancer Patients Undergoing Radiotherapy: A Randomized Controlled Clinical Trial
Zeppegno P, Krengli M, Ferrante D, Bagnati M, Burgio V, Farruggio S, Rolla R, Gramaglia C, Grossini E
Cancers · 21 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2021-04-07 · Cancers (Basel) · vol. 13 · issue 8 · p. 1752
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 43 citations · more than 95% of similar papers · 5.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 40 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Music Therapy and Health · Cancer survivorship and care · Cancer-related cognitive impairment studies
- Keywords
- TBARS, Medicine, Breast cancer, Anxiety, Randomized controlled trial, Depression (economics), Internal medicine, Quality of life (healthcare), Radiation therapy, Cancer, Oncology, Oxidative stress, Psychiatry, Lipid peroxidation
9 authors
From IT
- Patrizia ZeppegnoUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”
- Marco Krengli · correspondingUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”
- Daniela FerranteUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”; Piedmont Reference Center for Epidemiology and Cancer Prevention
- Marco BagnatiUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”
- Vincenzo BurgioUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”
- Serena FarruggioUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”
Abstract
The aim of this study was to assess the effects of psychotherapy with music intervention (PMI) on anxiety, depression, redox status, and inflammation in breast cancer patients undergoing radiotherapy (RT). This monocentric randomized clinical trial recruited 60 patients who had a breast cancer operation and were undergoing postoperative RT. Eligible patients were randomized (1:1) in two groups: the control group (CG) received treatment as usual (n = 30), i.e., RT alone; the intervention group (PMI) received RT and psychotherapy with music intervention (n = 30), which was delivered in a group setting. Five patients were excluded after randomization. Assessments were performed at baseline (T0), at the end of RT (T1), and three months after the end of RT (T2). The main objectives of the study were the assessment of anxiety/depression, plasma glutathione (GSH), and thiobarbituric acid reactive substances (TBARS) in the two arms of the study. Our findings revealed a positive effect of PMI on anxiety, depression, resilience, and quality of life. Furthermore, a positive effect of PMI on redox status was found for the first time. Thus, in the PMI group, we found a significant increase of GSH (mean change 2.2 95%, CI 0.7 to 3.7) and a significant reduction of TBARS (mean change -1.1 95%, CI -1.8 to -0.3) at T2 vs. T0.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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