Activation of Hair Cell Growth Factors by Linoleic Acid in Malva verticillata Seed
Ryu HS, Jeong J, Lee CM, Lee KS, Lee JN, Park SM, Lee YM
Molecules (Basel, Switzerland) · 24 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Ministry of Trade, Industry and Energy
- Government
- Korea Institute for Advancement of Technology
- Government
- Korea Institute for Advancement of Technology (KIAT)
- Grants
- Korea Institute for Advancement of Technology (P0002162)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-04-07 · Molecules · vol. 26 · issue 8 · p. 2117
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 46 citations · more than 97% of similar papers · 5.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Hair Growth and Disorders · Skin and Cellular Biology Research · Wound Healing and Treatments
- Keywords
- Wnt signaling pathway, Growth factor, Linoleic acid, Dihydrotestosterone, Cyclin D1, Cell growth, Vascular endothelial growth factor, Cell biology, Biology, Signal transduction, Chemistry, Biochemistry, Cell cycle, Cancer research, Cell, Hormone, Fatty acid, Receptor, Androgen
- MeSH
- hair follicle, cells, cultured, humans, malva, seeds, linoleic acid, intercellular signaling peptides and proteins, plant extracts, chemical fractionation, cell proliferation, gene expression, models, biological, wnt signaling pathway, biomarkers
7 authors
From KR
- Hwa Sun RyuKomipharm International (South Korea)
- JiYeon JeongKomipharm International (South Korea)
- Chun Mong Lee
- Kwang‐Sik Lee
- Jungno LeeKomipharm International (South Korea)
- Sung‐Min ParkKomipharm International (South Korea)
Abstract
Hair loss by excessive stress from work and lifestyle changes has become a growing concern, particularly among young individuals. However, most drugs for alopecia impose a plethora of side effects. We have found the powerful impact of Malva verticillata seed extracts on alleviating hair loss. This study further isolated effective chemicals in M. verticillata seed extracts by liquid silica gel column chromatography. Under the screening for the growth rate (%) of human follicles dermal papilla cells (HFDPCs), we identified linoleic acid (LA) and oleic acid in n-hexane of M. verticillate (MH)2 fraction. LA treatment activated Wnt/β-catenin signaling and induced HFDPCs growth by increasing the expression of cell cycle proteins such as cyclin D1 and cyclin-dependent kinase 2. LA treatment also increased several growth factors, such as vascular endothelial growth factor, insulin-like growth factor-1, hepatocyte growth factor, and keratinocyte growth factor, in a dose-dependent manner. Besides, LA significantly inhibited Dickkopf-related protein expression (DKK-1), a primary alopecia signaling by dihydrotestosterone. Our findings suggest that LA treatment may alleviate a testosterone-induced signaling molecule and induces HFDPCs growth by activating Wnt/β-catenin signaling.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.