A Dietary Intervention High in Green Leafy Vegetables Reduces Oxidative DNA Damage in Adults at Increased Risk of Colorectal Cancer: Biological Outcomes of the Randomized Controlled Meat and Three Greens (M3G) Feasibility Trial
Frugé AD, Smith KS, Riviere AJ, Tenpenny-Chigas R, Demark-Wahnefried W, Arthur AE, Murrah WM, van der Pol WJ, Jasper SL, Morrow CD, Arnold RD, Braxton-Lloyd K
Nutrients · 17 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- University or hospital
- Auburn University
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Government
- NIH HHS
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (R25CA047888); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-056336); National Institutes of Health (UL1TR003096)
Based on 7 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-04-07 · Nutrients · vol. 13 · issue 4 · p. 1220
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 43 citations · more than 97% of similar papers · 6.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 73 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Diet and metabolism studies · Nutrition, Genetics, and Disease
- Keywords
- Colorectal cancer, Leafy vegetables, Randomized controlled trial, Medicine, DNA damage, Genotoxicity, Oxidative damage, Environmental health, Oxidative stress, Cancer, Toxicology, Food science, Biology, Internal medicine, Biochemistry, DNA, Toxicity
- MeSH
- feces, humans, vegetables, colorectal neoplasms, feasibility studies, cross-over studies, biodiversity, phylogeny, oxidative stress, adult, middle aged, biomarkers
12 authors
From US
- Andrew D. Frugé · correspondingAuburn University
- Kristen S. SmithAuburn University
- Aaron J. RiviereAuburn University
- Rachel Tenpenny-ChigasAuburn University
- Wendy Demark‐WahnefriedUniversity of Alabama at Birmingham
- Anna E. ArthurUniversity of Illinois Urbana-Champaign
Abstract
Green leafy vegetables (GLV) may reduce the risk of red meat (RM)-induced colonic DNA damage and colorectal cancer (CRC). We previously reported the primary outcomes (feasibility) of a 12-week randomized controlled crossover trial in adults with habitual high RM and low GLV intake with body mass index (BMI) > 30 kg/m2 (NCT03582306). Herein, our objective was to report a priori secondary outcomes. Participants were recruited and enrolled in 2018, stratified by gender, and randomized to two arms: immediate intervention group (IG, n = 26) or delayed intervention group (DG, n = 24). During the 4 week intervention period, participants were provided with frozen GLV and counseled to consume 1 cooked cup equivalent daily. Participants consumed their normal diet for the remaining 8 weeks. At each of four study visits, anthropometrics, stool, and blood were taken. Overall, plasma Vitamin K1 (0.50 ± 1.18 ng/mL, p p p p < 0.001) decreased during the GLV intervention compared to control periods. Alpha diversity of fecal microbiota and relative abundance of major taxa did not differ systematically across study periods. Further investigation of the effects of increased GLV intake on CRC risk is warranted.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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