Mechanisms of PhotoBioModulation (PBM) focused on oral mucositis prevention and treatment: a scoping review
Courtois E, Bouleftour W, Guy JB, Louati S, Bensadoun RJ, Rodriguez-Lafrasse C, Magné N
BMC oral health · 44 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2021-04-29 · BMC Oral Health · vol. 21 · issue 1 · p. 220
- Publisher
- BioMed Central
- Cited
- 69 citations · more than 98% of similar papers · 6.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 47 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Keywords
- Medicine, Mucositis, Low level laser therapy, Chemoradiotherapy, Oral and maxillofacial surgery, Cancer, Cancer therapy, Radiation therapy, Cancer treatment, Oncology, Intensive care medicine, Bioinformatics, Internal medicine, Surgery, Laser therapy
- MeSH
- humans, neoplasms, stomatitis, prospective studies, chemoradiotherapy, low-level light therapy
7 authors
From US, FR
- Elodie CourtoisnLIGHT (United States)
- Wafa Bouleftour · correspondingInstitute Cancer De La Loire Lucien Neuwirth; Centre Hospitalier Universitaire de Saint-Étienne
- Jean‐Baptiste GuyInstitute Cancer De La Loire Lucien Neuwirth; Centre Hospitalier Universitaire de Saint-Étienne
- Safa LouatiInstitute Cancer De La Loire Lucien Neuwirth; Centre Hospitalier Universitaire de Saint-Étienne
- René‐Jean BensadounCentre de Haute Energie
- Claire Rodriguez‐LafrasseLyon 1 Université; Centre National de la Recherche Scientifique; Laboratoire de Biologie et Modélisation de la Cellule; Institute of Nuclear Physics of Lyon; Institut de Physique des 2 Infinis de Lyon
Abstract
Background
Oral mucositis (OM) is a severe complication cancer patients undergo when treated with chemoradiotherapy. Photobiomodulation (PBM) therapy also known as low-level laser therapy has been increasingly used for the treatment of such oral toxicity. The aim of this review is to discuss the mechanisms of photobiomodulation (PBM) regarding OM prevention and treatment, and more precisely to focus on the effect of PBM on tumor and healthy cells.
Methods
MEDLINE/PubMed, and google scholar were searched electronically. Selected studies were focusing on PBM effects on tumor and healthy cells.
Results
PBM interactions with the tissue and additional mechanism in OM therapy were detailed in this review. Moreover, this review highlighted a controversy about the carcinogenic effect of PBM. Indeed, Many studies reported that PBM could enhance malignant cell proliferation; suggesting that PBM would have no protective effect. In addition to acting on cancer cells, PBM may damage healthy cells.
Conclusion
More prospective studies are needed to assess the effect of PBM on cancer cells in order to improve its use for OM prevention and treatment.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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