Genetically determined variations of selenoprotein P are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins
Moriguchi Watanabe L, Bueno AC, de Lima LF, Ferraz-Bannitz R, Dessordi R, Guimarães MP, Foss-Freitas MC, Barbosa F, Navarro AM
The British journal of nutrition · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- University or hospital
- Universidade de São Paulo
Based on 1 listed funder(s).
Publication
- Published
- 2021-05-05 · Br J Nutr · vol. 127 · issue 5 · pp. 679–686
- Publisher
- Cambridge University Press
- Cited
- 30 citations · more than 94% of similar papers · 3.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Free to read
- Research areas
- Selenium in Biological Systems · Trace Elements in Health · Vitamin D Research Studies
- Keywords
- GPX1, Brazil nut, Single-nucleotide polymorphism, Selenoprotein, Glutathione peroxidase, Selenoprotein P, Biology, Internal medicine, Vitamin E, Endocrinology, Genotype, Antioxidant, Medicine, Genetics, Oxidative stress, Biochemistry, Superoxide dismutase, Gene, Food science
- MeSH
- humans, bertholletia, selenium, glutathione peroxidase, triglycerides, rna, messenger, hydroxymethylglutaryl-coa reductase inhibitors, antioxidants, selenoproteins, selenoprotein p, biomarkers
9 authors
From BR
- Lígia Moriguchi Watanabe · correspondingUniversidade de São Paulo
- Ana Carolina BuenoUniversidade de São Paulo
- Lívia Fernandes de LimaUniversidade de São Paulo
- Rafael Ferraz BannitzUniversidade de São Paulo
- Renata DessordiUniversidade Estadual Paulista (Unesp)
- Mariana P. GuimarãesUniversidade de São Paulo
Abstract
Several single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biomarkers to the Brazil nut consumption in patients using statins and if the variation in Se homoeostasis could affect antioxidant protection, lipid profile, muscle homoeostasis and selenoproteins mRNA. The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients using statins received one unit of Brazil nut daily for 3 months. Body composition, blood Se concentrations, erythrocyte glutathione peroxidase (GPX) activity, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triacylglycerol (TAG), creatine kinase (CK) activity and gene expression of GPX1 and selenoprotein P (SELENOP) were evaluated before and after Brazil nut consumption. The volunteers were genotyped for SNP in GPX1 (rs1050450) and SELENOP (rs3877899 and rs7579). SNPs in selenoproteins were not associated with plasma and erythrocyte Se, but SNPs in SELENOP influenced the response of erythrocyte GPX activity and CK activity, TAG and LDL after Brazil nut consumption. Also, Brazil nut consumption increased GPX1 mRNA expression only in subjects with rs1050450 CC genotype. SELENOP mRNA expression was significantly lower in subjects with rs7579 GG genotype before and after the intervention. Thus, SNP in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasising the involvement of genetic variability in response to Se consumption towards health maintenance and disease prevention.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.