The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study
Murphy C, Byrne J, Keogh JB, Headland ML, Clifton PM
International journal of environmental research and public health · 4 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2021-05-17 · Int J Environ Res Public Health · vol. 18 · issue 10 · p. 5303
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 6 citations · more than 61% of similar papers · 0.6× the field average
- References
- 63 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Cardiovascular Health and Disease Prevention
- Keywords
- Medicine, Endothelial dysfunction, Randomized controlled trial, Magnesium, Pathogenesis, Body mass index, Internal medicine, Blood pressure, Gastroenterology
- MeSH
- brachial artery, endothelium, vascular, humans, magnesium, pilot projects, cross-over studies, dietary supplements, female, male
5 authors
From AU, IE
- Caitríona MurphyUniversity of South Australia; Technological University Dublin
- Jennifer ByrneUniversity of South Australia; Technological University Dublin
- Jennifer B KeoghUniversity of South Australia
- Michelle Louise HeadlandUniversity of South Australia
- Peter Marshall Clifton · correspondingUniversity of South Australia
Abstract
Magnesium (Mg) deficiency might be a catalyst in the process of endothelial dysfunction, an early event in the pathogenesis of atherosclerosis. The aim of this study was to determine the acute effect of an oral Mg supplement as compared to control on endothelial function assessed by flow-mediated dilatation (FMD). Nineteen participants (39 years, body mass index (BMI) 22.9 kg/m2) completed this randomized cross-over study. Blood pressure (BP) and FMD were measured and blood samples were taken before participants drank 200 mL water, with or without an over the counter Mg supplement (450 mg and 300 mg for men and women). Measurements were repeated at 60 and 120 min. There was a statistically significant two-way interaction between treatment and time on serum Mg (p = 0.037). A difference of -0.085 mm in FMD was observed 60-min post drink in the control group, as compared to baseline FMD, and no difference was observed in the supplement group as compared to baseline. Despite the non-significant interaction between treatment and time on FMD, once adjusted for baseline, the difference seen in the control group and the lack of change in the supplement group at 60 min post-drink suggests that Mg might attenuate the reduction in FMD post-prandially.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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