Metabolic and hormonal effects of melatonin and/or magnesium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial
Alizadeh M, Karandish M, Asghari Jafarabadi M, Heidari L, Nikbakht R, Babaahmadi Rezaei H, Mousavi R
Nutrition & metabolism · 37 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Ahvaz Jundishapur University of Medical Sciences
- University or hospital
- University of Tabriz
- University or hospital
- Tabriz University of Medical science
- Grants
- Ahvaz Jundishapur University of Medical Sciences (NRC-9815)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-06-06 · Nutr Metab (Lond) · vol. 18 · issue 1 · p. 57
- Publisher
- BioMed Central
- Cited
- 52 citations · more than 93% of similar papers · 3.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 63 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Ovarian function and disorders · Menopause: Health Impacts and Treatments
- Keywords
- Melatonin, Polycystic ovary, Endocrinology, Internal medicine, Medicine, Placebo, Insulin resistance, Testosterone (patch), Lipid profile, Insulin, Cholesterol
7 authors
From IR
- Mohammad AlizadehUniversity of Tabriz
- Majid KarandishAhvaz Jundishapur University of Medical Sciences
- Mohammad Asghari JafarabadiZanjan University of Medical Sciences; University of Tabriz
- Lida HeidariIsfahan Fertility and Infertility Center
- Roshan NikbakhtAhvaz Jundishapur University of Medical Sciences
- Hossein Babaahmadi‐RezaeiAhvaz Jundishapur University of Medical Sciences
Abstract
Background
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. This study was designed to investigate the effects of melatonin and/or magnesium supplementation on metabolic profile and levels of sex hormones in PCOS women.
Methods
In an 8-week randomized double-blind placebo-controlled trial, 84 subjects with PCOS aged 18-40 years were randomly assigned based on the random block procedure to take magnesium, melatonin, magnesium plus melatonin, and placebo. Fasting blood samples were obtained at the beginning and end of the study.
Results
After intervention, the mean Pittsburg Sleep Quality Index score decreased significantly in both co-supplementation and melatonin groups (P < 0.001). Magnesium supplementation in combination with melatonin resulted in a significant greater decrease in testosterone concentrations compared with the placebo (P < 0.05). Co-supplementation of magnesium-melatonin had significantly reduced serum insulin levels (geometric means difference: - 1.11 (mIU/mL) (percent change: - 15.99)), homeostasis model of assessment-insulin resistance (HOMA-IR) (- 0.28 (- 18.66)), serum cholesterol (mean difference: - 16.08 (mg/dl) [95% CI - 24.24, - 7.92]), low-density lipoprotein cholesterol (LDL-C) - 18.96 (mg/dl) [- 28.73, - 9.20]) and testosterone levels (- 0.09 (ng/ml) (- 25.00)), as compared to the baseline values (P < 0.05). An increase in serum high-density lipoprotein cholesterol (HDL-C) levels was also observed following the administration of the melatonin alone (2.76 (mg/dl) [0.57, 4.95]) or in combination with magnesium (2.19 (mg/dl) [0.61, 3.77]) (P < 0.05).
Conclusions
Co-supplementation with magnesium and melatonin had beneficial effects on sleep quality and total testosterone. Additionally, melatonin supplementation alone was found to be associated with a significant reduction in PSQI score. Moreover, combined melatonin and magnesium supplementation was more effective in improving serum levels of cholesterol, LDL-C, HDL-C and insulin, and HOMA-IR.
Trial registration
Iranian Registry of Clinical Trial. http://www.irct.ir : IRCT20191130045556N1, January 2020.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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