Dietary intakes of green leafy vegetables and incidence of cardiovascular diseases
Ojagbemi A, Okekunle AP, Olowoyo P, Akpa OM, Akinyemi R, Ovbiagele B, Owolabi M
Cardiovascular journal of Africa · 10 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Human Genome Research Institute
- Government
- National Institute of Neurological Disorders and Stroke
- Government
- NINDS NIH HHS
- Government
- NHGRI NIH HHS
- Government
- NHLBI NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (R01HL152188); National Institute of Neurological Disorders and Stroke (R01 NS115944); National Human Genome Research Institute (U54 HG007479); National Institute of Neurological Disorders and Stroke (R01 NS107900); National Human Genome Research Institute (U24 HG009780)
Based on 6 listed funder(s).
Publication
- Published
- 2021-08-31 · Cardiovasc J Afr · vol. 32 · issue 4 · pp. 43–51
- Publisher
- Clinics Cardive Publishing
- Cited
- 27 citations · more than 92% of similar papers · 3.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 61 works
- Access
- Open access (repository copy)
- Research areas
- Seed and Plant Biochemistry · Antioxidant Activity and Oxidative Stress · Nutritional Studies and Diet
- Keywords
- Medicine, Incidence (geometry), Relative risk, Meta-analysis, Confidence interval, Cochrane Library, Cohort study, Disease, Environmental health, Internal medicine
- MeSH
- humans, vegetables, cardiovascular diseases, incidence, primary prevention, eating
7 authors
From NG, US
- Akin OjagbemiUniversity of Ibadan
- Akinkunmi Paul OkekunleUniversity of Ibadan; University College Hospital, Ibadan
- Paul OlowoyoAfe Babalola University
- Onoja Matthew AkpaUniversity of Ibadan
- Rufus AkinyemiUniversity of Ibadan
- Bruce OvbiageleUniversity of California, San Francisco
Abstract
Aim
Low- and middle-income countries (LMICs) are currently experiencing increasing cardiovascular disease (CVD) rates. Green leafy vegetables (GLV), which are abundant in these countries, are known to be particularly rich in cardioprotective nutrients. This study sought to determine the specific effect of GLV intake on the incidence of CVD.
Methods
Previously published cohort studies on GLV intake and incidence of CVD were retrieved through a systematic search of Google Scholar, EMBASE, MEDLINE, HINARI and Cochrane Library. A methodological evaluation of studies was carried out using the network of Ottawa scale, and a fixed-effect meta-analysis was applied to estimate pooled relative risk (RR) and 95% confidence interval (CI). Heterogeneity was determined using the I2 statistic. Sensitivity analysis was done using the leave-one-study-out technique. All statistical analysis was carried out at p < 0.05 using RevMan 5.4.
Results
The pooled RR (95% CI) of incident CVD events from 17 studies was 0.93 (0.92-0.95). Specifically, GLV intake was inversely related with incident cerebral infarction (RR: 0.92; 95% CI: 0.88-0.96), heart disease (RR: 0.93; 95% CI: 0.87-0.99) and other CVD events (RR: 0.95; 95% CI: 0.93-0.98).
Conclusions
GLV intake was associated with a lower incidence of CVD, and may be a promising primary-prevention strategy against CVD events. The findings are especially important in LMICs where the burden of CVD remains high.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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