Vocal Music Listening Enhances Poststroke Language Network Reorganization
Sihvonen AJ, Ripollés P, Leo V, Saunavaara J, Parkkola R, Rodríguez-Fornells A, Soinila S, Särkämö T
eNeuro · 26 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Academy of Finland
- Nonprofit
- Suomen Kulttuurirahasto
- Nonprofit
- Signe ja Ane Gyllenbergin Säätiö
- Nonprofit
- Orionin Tutkimussäätiö
- Nonprofit
- Suomen Aivosäätiö
- University or hospital
- Varsinais-Suomen Sairaanhoitopiiri
- Nonprofit
- Suomen Aivotutkimus- ja Kuntoutussäätiö
- Government
- European Research Council
- Government
- H2020 European Research Council
- Government
- Suomen Akatemia
- Nonprofit
- Finnish Brain Research and Rehabilitation Foundation
- University or hospital
- Tyks Research Funding
- Grants
- Academy of Finland (257077); H2020 European Research Council (803466); Academy of Finland (257077, 277693, 299044); European Research Council (803466); Suomen Kulttuurirahasto (#191230); Academy of Finland (277693); Academy of Finland (299044)
Based on 12 listed funder(s).
Publication
- Published
- 2021-06-17 · eNeuro · vol. 8 · issue 4 · pp. ENEURO.0158–21.2021
- Publisher
- Society for Neuroscience
- Cited
- 39 citations · more than 92% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 97 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Neurobiology of Language and Bilingualism · Neuroscience and Music Perception · Music Therapy and Health
- Keywords
- Neuroplasticity, Active listening, Psychology, Stimulus (psychology), Vocal tract, Music therapy, Audiology, Rehabilitation, Stroke (engine), Medicine, Physical medicine and rehabilitation, Cognitive psychology, Neuroscience, Communication, Psychotherapist
- MeSH
- brain, neural pathways, humans, magnetic resonance imaging, music therapy, single-blind method, language, auditory perception, recovery of function, neuronal plasticity, music, aged, middle aged, female, male, stroke, diffusion tensor imaging, stroke rehabilitation
8 authors
From FI, AU, US, ES
- Aleksi J. SihvonenUniversity of Helsinki; The University of Queensland
- Pablo RipollésNew York University
- Vera LeoUniversity of Helsinki
- Jani P. SaunavaaraTurku University Hospital
- Riitta ParkkolaUniversity of Turku; Turku University Hospital
- Antoni Rodríguez‐FornellsInstitució Catalana de Recerca i Estudis Avançats; Bellvitge University Hospital; Institut d'Investigació Biomédica de Bellvitge; Manufacturas Serviplast (Spain); Universitat de Barcelona
Abstract
Listening to vocal music has been recently shown to improve language recovery in stroke survivors. The neuroplasticity mechanisms supporting this effect are, however, still unknown. Using data from a three-arm, single-blind, randomized controlled trial including acute stroke patients (N = 38) and a 3 month follow-up, we set out to compare the neuroplasticity effects of daily listening to self-selected vocal music, instrumental music, and audiobooks on both brain activity and structural connectivity of the language network. Using deterministic tractography, we show that the 3 month intervention induced an enhancement of the microstructural properties of the left frontal aslant tract (FAT) for the vocal music group compared with the audiobook group. Importantly, this increase in the strength of the structural connectivity of the left FAT correlated with improved language skills. Analyses of stimulus-specific activation changes showed that the vocal music group exhibited increased activations in the frontal termination points of the left FAT during vocal music listening compared with the audiobook group from acute to 3 month poststroke stage. The increased activity correlated with the structural neuroplasticity changes in the left FAT. These results suggest that the beneficial effects of vocal music listening on poststroke language recovery are underpinned by structural neuroplasticity changes within the language network and extend our understanding of music-based interventions in stroke rehabilitation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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