Beneficial effects of dietary supplementation with olive oil, oleic acid, or hydroxytyrosol in metabolic syndrome: Systematic review and meta-analysis
Pastor R, Bouzas C, Tur JA
Free radical biology & medicine · 75 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- European Cooperation in Science and Technology
- Government
- Instituto de Salud Carlos III
- Government
- European Regional Development Fund
- Government
- COST
- Grants
- Instituto de Salud Carlos III (RD06/0045); European Regional Development Fund (35/2011); European Regional Development Fund (CA16112); Instituto de Salud Carlos III (RD06/0045/1004); European Regional Development Fund (RD06/0045/1004); European Regional Development Fund ((RD 06/0045); European Regional Development Fund (CB12/03); Instituto de Salud Carlos III (Red Predimed-RETIC RD06/0045/1004); Instituto de Salud Carlos III (RETIC RD06/0045/1004); Instituto de Salud Carlos III (35/2011)
Based on 4 listed funder(s).
Publication
- Published
- 2021-06-18 · Free Radic Biol Med · vol. 172 · pp. 372–385
- Publisher
- Elsevier BV
- Cited
- 119 citations · more than 61% of similar papers · 0.8× the field average
- References
- 136 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Edible Oils Quality and Analysis · Fatty Acid Research and Health · Nuts composition and effects
- Keywords
- Hydroxytyrosol, Oleic acid, Cochrane Library, Insulin resistance, Medicine, Metabolic syndrome, Antioxidant, Meta-analysis, Food science, Internal medicine, Obesity, Chemistry, Biochemistry, Polyphenol
- MeSH
- humans, phenylethyl alcohol, oleic acid, dietary supplements, olive oil, metabolic syndrome
3 authors
From ES
- Rosario PastorCatholic University of Ávila; Research Institute of Health Sciences; Universitat de les Illes Balears
- Cristina BouzasCatholic University of Ávila; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Research Institute of Health Sciences; Universitat de les Illes Balears
- Josep Antoni Tur · correspondingInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Research Institute of Health Sciences; Universitat de les Illes Balears
Abstract
Background and aims
Olive oil and components might have a beneficial effect on Metabolic Syndrome (MetS). The aim of this review and meta-analysis was to assess whether those effects are related to hydroxytyrosol or oleic acid contents, or the combination of them as olive oil, and how powerful is this effect.
Methods
A systematic literature search was performed in MEDLINE via Pubmed, Web of Science (WOS) core collection, and Virtual Health Library (VHL) via LILACS and IBECS (Spain). MeSH terms used were "obesity", "body weight", "body mass index", "adipose tissue", "lipid metabolism", "LDL", "HDL", "VLDL", "insulin resistance", "glucose", "insulin", "hypertension", "arterial pressure", "olive oil", "oleic acid", and other (non-MeSH) terms: "total antioxidant capacity", "total antioxidant status", "hydroxytyrosol" (PROSPERO ID: CRD42021247614). Results of the included studies were meta-analyzed with the RevMan 5.3 program, assuming a random effects model.
Results
76 articles (67 different trials) were identified. Hydroxytyrosol had no effect on MetS [combined standardized mean differences (SMD) = 0.01 (CI 95%: [-0.23, 0.25], I2 = 83%; p = 0.920)]. Oleic acid had no significant beneficial effect on MetS [SMD = 0.03 (CI 95%: [-0.01, 0.07], I2 = 0%); p = 0.150], but it improved lipid profile [SMD = 0.06 (CI 95%: [-0.00, 0.12], I2 = 0%); p = 0. 050]. Olive oil had no effect on MetS [SMD = -0.01 (CI 95%: [-0.05, 0.03]), I2 = 55%; p = 0.550)]. The supplementation with hydroxytyrosol, oleic acid or olive oil showed a beneficial effect on antioxidant capacity related to components of MetS [SMD = 0.31 (CI 95%: [-0.34, 0.95], I2 = 81%)]; p = 0.35).
Conclusion
Most articles compared olive oil and oleic acid with other strategies specially designed for MetS management. Our findings suggest that olive oil or oleic acid consumption are as good as the other strategies to manage MetS.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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