Body mass-normalized moderate dose of dietary nitrate intake improves endothelial function and walking capacity in patients with peripheral artery disease
Pekas EJ, Wooden TK, Yadav SK, Park SY
American journal of physiology. Regulatory, integrative and comparative physiology · 24 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Nebraska Space Grant Consortium
- Government
- National Institute of General Medical Sciences
- University or hospital
- University of Nebraska at Omaha
- Government
- NASA Nebraska Space Grant
- Government
- NIGMS NIH HHS
- Government
- Center for Research in Human Movement Variability National Institutes of Health
- Government
- HHS | NIH | National Institute of General Medical Sciences
- Government
- NASA Nebraska Space Grant Fellowship
- Grants
- National Institute of General Medical Sciences (P20GM109090); Nebraska Space Grant Consortium (NNX15AI09H)
Based on 8 listed funder(s).
Publication
- Published
- 2021-06-23 · Am J Physiol Regul Integr Comp Physiol · vol. 321 · issue 2 · pp. R162–R173
- Publisher
- American Physiological Society
- Cited
- 33 citations · more than 95% of similar papers · 4.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 82 works
- Access
- Open access (repository copy)
- Research areas
- Peripheral Artery Disease Management · Cerebrovascular and Carotid Artery Diseases · Cardiovascular Health and Disease Prevention
- Keywords
- Claudication, Pulse wave velocity, Brachial artery, Medicine, Blood pressure, Crossover study, Nitrate, Internal medicine, Arterial stiffness, Nitrite, Cardiology, Placebo, Hemoglobin, Vasodilation, Anesthesia, Vascular disease, Chemistry, Arterial disease, Pathology
- MeSH
- endothelium, vascular, humans, beta vulgaris, intermittent claudication, nitrates, body mass index, treatment outcome, walking, cross-over studies, double-blind method, recovery of function, blood pressure, vasodilation, exercise tolerance, time factors, aged, middle aged, nebraska, female, male, peripheral arterial disease, vascular stiffness, fruit and vegetable juices
4 authors
From US
- Elizabeth J. PekasUniversity of Nebraska at Omaha
- TeSean K. WoodenUniversity of Nebraska at Omaha
- Santosh Kumar YadavUniversity of Nebraska Medical Center
- Song‐Young Park · correspondingUniversity of Nebraska at Omaha
Abstract
Peripheral artery disease (PAD) is characterized by the accumulation of atherosclerotic plaques in the lower extremity conduit arteries, which impairs blood flow and walking capacity. Dietary nitrate has been used to reduce blood pressure (BP) and improve walking capacity in PAD. However, a standardized dose for PAD has not been determined. Therefore, we sought to determine the effects of a body mass-normalized moderate dose of nitrate (0.11 mmol nitrate/kg) as beetroot juice on serum nitrate/nitrite, vascular function, walking capacity, and tissue oxygen utilization capacity in patients with PAD. A total of 11 patients with PAD received either nitrate supplement or placebo in a randomized crossover design. Total serum nitrate/nitrite, resting BP, brachial and popliteal artery endothelial function (flow-mediated dilation, FMD), arterial stiffness (pulse-wave velocity, PWV), augmentation index (AIx), maximal walking distance and time, claudication onset time, and skeletal muscle oxygen utilization were measured pre- and postnitrate and placebo intake. There were significant group × time interactions (P P > 0.05). These results indicate that a body-mass normalized moderate dose of nitrate may be effective and safe for reducing BP, improving endothelial function, and improving walking capacity in patients with PAD.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.