Clinical research: low-level laser therapy in accelerating orthodontic tooth movement
Zheng J, Yang K
BMC oral health · 42 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- University or hospital
- 'Beijing Hospitals Authority' Ascent Plan
- University or hospital
- ‘Beijing Hospitals Authority’ Ascent Plan
- Government
- National Nature Science Foundation of China
- Grants
- National Natural Science Foundation of China (81771103); National Natural Science Foundation of China (DFL20191501)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-06-28 · BMC Oral Health · vol. 21 · issue 1 · p. 324
- Publisher
- BioMed Central
- Cited
- 83 citations · more than 98% of similar papers · 7.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 19 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Laser Applications in Dentistry and Medicine · Salivary Gland Disorders and Functions · Oral microbiology and periodontitis research
- Keywords
- Medicine, Osteoprotegerin, Low level laser therapy, RANKL, Dentistry, Oral and maxillofacial surgery, Bone remodeling, Orthodontics, Laser therapy, Internal medicine, Laser, Activator (genetics), Receptor
- MeSH
- gingival crevicular fluid, bicuspid, humans, lasers, semiconductor, low-level light therapy, tooth movement techniques
2 authors
From CN
- Junyi ZhengCapital Medical University
- Kai Yang · correspondingCapital Medical University; Beijing Tian Tan Hospital
Abstract
Background
The present study aimed to investigate the effects of low-level laser therapy (LLLT) on orthodontic tooth movement and its correlation with the levels of interleukin-1β (IL-1β), receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in gingival crevicular fluid (GCF).
Methods
This split-mouth design study included 12 patients scheduled for the extraction of both upper first premolars. Patients were randomly selected for experimental group that received left- or right-side radiation with a diode laser (810 nm wavelength, 100 mW power output, 6.29 J/cm2 energy density). Laser treatment was applied on days 0, 7, 14, and 21, after loading the canine retraction forces. GCF concentrations of IL-1β, RANKL, and OPG were analyzed. The upper arch of each patient was scanned with an intraoral scanner to assess tooth movement.
Results
The cumulative tooth movement over 28 days was significantly higher in the laser group than in the control group. We observed significant reductions in OPG levels and increases in IL-1β and RANKL levels in GCF samples on the experimental sides.
Conclusion
With the parameter settings used in this study, LLLT could, to some extent, lead to changes in bone metabolism, which could accelerate orthodontic tooth movement.
Trial registration
Chinese Clinical Trial Registry, ChiCTR2000039594. Registered 2 November 2020-Retrospectively registered, www.chictr.org.cn/edit.aspx?pid=62465&htm=4 .
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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