Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms
Abiri B, Sarbakhsh P, Vafa M
Nutritional neuroscience · 32 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institute for Medical Research Development
- Grants
- National Institute for Medical Research Development (982923)
Based on 1 listed funder(s).
Publication
- Published
- 2021-07-02 · Nutr Neurosci · vol. 25 · issue 10 · pp. 2123–2135
- Publisher
- Taylor & Francis
- Cited
- 49 citations · more than 91% of similar papers · 3.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 65 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease · Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Mood, Inflammation, Randomized controlled trial, Depressive symptoms, Medicine, Internal medicine, Vitamin D and neurology, Vitamin, Endocrinology, Psychology, Physical therapy, Anxiety, Clinical psychology, Psychiatry
- MeSH
- humans, obesity, inflammation, magnesium, brain-derived neurotrophic factor, vitamins, vitamin d, tumor necrosis factor-alpha, c-reactive protein, interleukin-6, double-blind method, depression, dietary supplements, female, sirtuin 1
3 authors
From IR
- Behnaz AbiriResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Parvin SarbakhshTabriz University of Medical Sciences
- Mohammadreza Vafa · correspondingIran University of Medical Sciences
Abstract
Objectives
This study aimed to evaluate the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms.
Methods
In this trial, the 108 obese women with mild to moderate depressive symptoms were randomly allocated into 4 groups: (1) co- supplementation group (n = 27): receiving a 50000 IU vitamin D soft gel weekly + a 250- mg magnesium tablet daily; (2) vitamin D group (n = 27): receiving a 50000 IU vitamin D soft gel weekly + a magnesium placebo daily; (3) magnesium group (n = 27): receiving a vitamin D placebo weekly + a 250- mg magnesium tablet daily; (4) control group (n = 27): receiving a vitamin D placebo weekly + a magnesium placebo daily, for 8 weeks. Before and after the intervention, anthropometric indices, depressive symptoms, serum levels of BDNF, 25(OH)-D, inflammation, and SIRT1, were measured.
Results
At the end of the study, ANCOVA demonstrated significant differences between the 4 groups in 25(OH)-D, magnesium, TNF-α, IL-6, and BDNF levels. But, we found no significant differences in terms of hs-CRP and SIRT1 levels. A significant reduction in depression score was observed in 3 intervention groups and also in control group. No significant differences in BDI-II score were shown among the 4 groups at the end of the intervention.
Conclusion
Vitamin D plus magnesium supplementation in obese women with mild to moderate depressive symptoms has beneficial influences on mood, serum levels of BDNF, inflammation, and SIRT1.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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