Association of Coffee and Caffeine Intake With Irritable Bowel Syndrome in Adults
Koochakpoor G, Salari-Moghaddam A, Keshteli AH, Esmaillzadeh A, Adibi P
Frontiers in nutrition · 19 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Isfahan University of Medical Sciences
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-06-15 · Front Nutr · vol. 8 · p. 632469
- Publisher
- Frontiers Media
- Cited
- 37 citations · more than 94% of similar papers · 4.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Gastrointestinal motility and disorders · Diet and metabolism studies · Digestive system and related health
- Keywords
- Caffeine, Medicine, Odds ratio, Irritable bowel syndrome, Confounding, Odds, Cross-sectional study, Internal medicine, Logistic regression
5 authors
From IR, CA
- Glareh KoochakpoorUniversity of Maragheh; Maragheh University of Medical Sciences
- Asma Salari-MoghaddamTehran University of Medical Sciences
- Ammar Hassanzadeh KeshteliUniversity of Alberta
- Ahmad Esmaillzadeh · correspondingIsfahan University of Medical Sciences; Obesity and Eating Habits Research Center; Tehran University of Medical Sciences
- Peyman AdibiIsfahan University of Medical Sciences
Abstract
The aim of this study was to investigate the association between coffee and caffeine intake and odds of IBS and its severity in adult population. In this cross-sectional study, dietary intakes of 3,362 Iranian adults were examined using a validated dish-based 106-item Semi-quantitative Food Frequency Questionnaire (DS-FFQ). Coffee and caffeine intake was assessed using the DS-FFQ. IBS was assessed using a modified Persian version of Rome III questionnaire. After adjustment for potential confounders, we found that individuals who were taking coffee weekly or more had greater odds of IBS (OR:1.44; 95% CI: 1.02-2.04) than those who never drinking coffee. In addition, participants in the top tertile of caffeine intake (≥106.5 mg/d) had 47% greater odds of IBS compared to those in the bottom tertile (2 (OR for those in the highest tertile vs. lowest tertile: 1.72; 95% CI: 1.20-2.48). There was a significant association between caffeine intake and IBS severity among subjects with BMI ≥ 25 kg/m2 (OR: 1.04; 95% CI: 1.01-2.62). In conclusion, coffee and caffeine consumption was associated with increased odds of IBS in the whole study population. The association between caffeine and odds of IBS was also significantly positive among women and overweight or obese subjects (BMI ≥ 25 kg/m2). In addition, we found a significant relationship between caffeine intake and severity of IBS symptoms among overweight or obese subjects (BMI ≥ 25 kg/m2).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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