Effect of oral magnesium supplementation for relieving leg cramps during pregnancy: A meta-analysis of randomized controlled trials
Liu J, Song G, Zhao G, Meng T
Taiwanese journal of obstetrics & gynecology · 8 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Grants
- National Natural Science Foundation of China (81871173)
Based on 1 listed funder(s).
Publication
- Published
- 2021-07-01 · Taiwan J Obstet Gynecol · vol. 60 · issue 4 · pp. 609–614
- Publisher
- Elsevier BV
- Cited
- 20 citations · more than 60% of similar papers · 0.6× the field average
- References
- 27 works
- Access
- Open access (free to publish) · CC-BY-NC-ND
- Research areas
- Pregnancy-related medical research · Electrolyte and hormonal disorders · Restless Legs Syndrome Research
- Keywords
- Medicine, Randomized controlled trial, Pregnancy, Odds ratio, Muscle cramp, Confidence interval, Childbirth, Calf muscle, Physical therapy, Anesthesia, Surgery, Internal medicine
- MeSH
- leg, humans, muscle cramp, pregnancy complications, magnesium, treatment outcome, administration, oral, pregnancy, dietary supplements, female, randomized controlled trials as topic
4 authors
From CN
- Jing LiuFirst Hospital of China Medical University; China Medical University
- Guang SongChina Medical University
- Ge ZhaoFirst Hospital of China Medical University; China Medical University
- Tao Meng · correspondingFirst Hospital of China Medical University; China Medical University
Abstract
Leg cramps are one of the common symptoms during pregnancy. About 30%-50% of pregnant women experience leg cramps twice a week. Leg cramps may cause severe pain and sleep disturbance, hinder performance of daily activities and may lengthen the duration of pregnancy and the type of childbirth. Several randomized controlled trial (RCT) studies focused on the effects of the magnesium supplement for relieving leg cramps. However, the results were inconsistent. Five databases were searched from their inception to July 2, 2020. We summarized the weighted mean difference (WMD) with 95% CIs for "the frequency of leg cramps after treatment", and summarized the odds ratio (OR) with 95% confidence intervals (CIs) for "recovery from leg cramps" and "side effects". Four RCTs with a total of 332 pregnant women were identified. The frequency of leg cramps after treatment was not decreased in the treatment group compared to the control group (WMD = -0.47, 95% CI: -1.14-0.20, P = 0.167). Magnesium supplementation cannot improve the recovery from leg cramps compared to the control group (OR = 0.47, 95% CI: 0.14-1.52, P = 0.207). Magnesium supplementation had no significant side effects in the treatment group compared to the control group (OR = 1.82, 95% CI: 0.90-3.69, P = 0.094). Oral magnesium supplementation is not effective in the treatment of leg cramps during pregnancy. PROSPERO: CRD42020196572.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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